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Article
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AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button.
Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Human Health Effects
Nanoplastics
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Polystyrene nanoplastics target lysosomes interfering with lipid metabolism through the PPAR system and affecting macrophage functionalization
Environmental Science Nano
2023
24 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
I. Brandts,
Roger Solà,
Marlid Garcia-Ordoñez,
Alejandro Gella,
Albert Quintana,
Beatriz Martín‐Mur,
Anna Esteve‐Codina,
Mariana Teles,
Nerea Roher
Summary
Researchers examined how polystyrene nanoplastics affect lysosomal function and lipid metabolism in macrophages through the PPAR signaling system. The study suggests that nanoplastics can interfere with cellular lipid processing by targeting lysosomes, which may affect immune cell function.
Nanoplastics (NPs) are currently a main concern for environmental, animal and human health due to their potential to accumulate in different environmental compartments and provoke effects in living organisms.