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Article
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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
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Wistar Rats Hippocampal Neurons Response to Blood Low-Density Polyethylene Microplastics: A Pathway Analysis of SOD, CAT, MDA, 8-OHdG Expression in Hippocampal Neurons and Blood Serum Aβ42 Levels
Neuropsychiatric Disease and Treatment
2023
27 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Yudhiakuari Sincihu,
Muhammad Farid Dimjati Lusno,
Tri Marthy Mulyasari,
Saliza Mohd Elias,
I Ketut Sudiana,
Kurnia Kusumastuti,
Lilis Sulistyorini,
Soedjajadi Keman
Summary
Researchers investigated the effects of blood-borne low-density polyethylene microplastics on hippocampal neurons in Wistar rats. Pathway analysis showed that microplastic particles in the blood significantly affected hippocampal neurons, with changes observed in oxidative stress markers SOD, CAT, MDA, and 8-OHdG expression as well as blood serum amyloid-beta 42 levels.
The pathway analysis showed that hippocampal neurons were significantly affected by microplastic particles in the blood.