We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Transcriptome sequencing and metabolite analysis reveal the single and combined effects of microplastics and di-(2-ethylhexyl) phthalate on Peneaus vannamei
Summary
Researchers used transcriptomics and metabolomics to study the individual and combined effects of microplastics and the plasticizer DEHP on shrimp. Both pollutants disrupted antioxidant defense systems and altered amino acid and lipid metabolism, leading to inflammatory responses. Interestingly, the presence of microplastics appeared to partially reduce the toxicity of DEHP, suggesting complex interactions between plastic particles and their chemical additives in marine organisms.
Due to the rising usage of plastics, plastic debris are present throughout marine ecosystems and detrimentally affects marine biota. Additionally, plastics likely result in elusive toxicity effects due to addition of plasticizers. The aim of the present study was to reveal the potential effects and mechanism of microplastics (MPs), di-(2-ethylhexyl) phthalate (DEHP) and copollution of MPs and DEHP (MPs-DEHP) on Peneaus vannamei (P. vannamei) juveniles regarding oxidative stress, transcriptomics and metabolomics. MPs, DEHP and MPs-DEHP significantly induced the activities of superoxide dismutase (SOD) and catalase (CAT); MPs and DEHP have an antagonistic effect for malondialdehyde (MDA); suggesting that disorders of the antioxidant defence systems. 13, 133 and 58 differentially expressed genes and 21, 82 and 39 differentially expressed metabolites were responsible for the distinction of MPs, DEHP and MPs-DEHP groups, respectively. The combination of transcriptomic and metabolomic analyses showed that MPs, DEHP and MPs-DEHP exposure disturbed amino acid and lipid metabolism, and further induced inflammatory responses and dysfunction of purine metabolism. Furthermore, the presence of MPs might alleviate the biotoxicity of DEHP in P. vannamei. These findings provide new insights into the single and combined toxicological effects of MPs and additives for marine biota.
Sign in to start a discussion.
More Papers Like This
Combined ecotoxicity of polystyrene microplastics and Di-(2-ethylhexyl) phthalate increase exposure risks to Mytilus coruscus based on the bioaccumulation, oxidative stress, metabolic profiles, and nutritional interferences
Researchers exposed hard-shelled mussels to a common plastic additive (DEHP) and polystyrene microplastics together, and found that the microplastics increased how much DEHP accumulated in the animals' digestive organs. The combined exposure disrupted the mussels' antioxidant defenses and altered their metabolic processes more than either pollutant alone. The study suggests that microplastics can amplify the harmful effects of chemical pollutants in marine organisms.
Toxicities of polystyrene microplastics (MPs) and hexabromocyclododecane (HBCD), alone or in combination, to the hepatopancreas of the whiteleg shrimp, Litopenaeus vannamei
Researchers studied the combined effects of polystyrene microplastics and a flame retardant chemical (HBCD) on the liver-like organ of whiteleg shrimp. The combination caused more severe damage than either pollutant alone, disrupting metabolism and triggering oxidative stress. This matters because microplastics in the ocean commonly carry absorbed chemical pollutants, making real-world exposure potentially more harmful than single-pollutant studies suggest.
Revealing the effects of polystyrene microplastics and di(2-ethylhexyl) phthalate on mussels:An evidence chain of gill-intestine-hemolymph
Researchers exposed mussels to polystyrene microplastics combined with the plasticizer DEHP for 30 days and found a cascade of harmful effects across gill, intestine, and blood systems. The combination caused gill damage, disrupted energy metabolism, triggered oxidative stress, altered gut microbiota, and suppressed immune function. The study establishes a pollutant cascade mechanism linking tissue damage, metabolic changes, and microbial imbalance in marine organisms.
Transcriptome Sequencing and Metabolite Analysis Revealed the Single and Combined Effects of Microplastics and Di-(2-ethylhexyl) Phthalate on Mouse Liver
Mice exposed to microplastics, the plasticizer DEHP, or both together showed liver damage including oxidative stress, cell death, and disrupted metabolism. The combined exposure was worse than either pollutant alone, activating cancer-related genes and impairing the liver's ability to process fats and amino acids. Since DEHP is commonly found alongside microplastics in the environment, these findings suggest that real-world exposure to contaminated plastics could pose a greater liver health risk than previously estimated.
Toxic effects of microplastics and nitrite exposure on intestinal histology, digestion, immunity, and microbial community of shrimp Litopenaeus vannamei
Shrimp exposed to both microplastics and nitrite (a common water pollutant) suffered more intestinal damage than those exposed to either pollutant alone. The combined exposure disrupted gut bacteria, increased stress and cell death markers, and weakened immune function in the shrimp. While this study focused on aquatic animals, it shows how microplastics can amplify the harmful effects of other environmental pollutants.