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Asthma and allergic diseases: Cross talk of immune system and environmental factors
Summary
This review summarizes current understanding of how environmental factors, including the microbiome and geographic location, influence immune regulation in the context of allergy and asthma. Researchers examined how different routes of exposure to environmental agents interact with both innate and adaptive immune responses. The study highlights the need for comprehensive investigation of environmentally driven immune changes to better understand disease prevention and progression.
Air pollution and immune-related diseases including allergy and asthma are constantly on the rise worldwide. Thus, a comprehensive investigation of environmentally induced immune regulation is required for a deeper understanding of disease pathogenesis, progression as well as prevention. Here, we summarize the current knowledge on environmental factors such as microbiome or geographical locations with harmful or protective effects for human health and their different routes of exposure. This review comprises a brief outline regarding the latest findings on the interaction of environmental factors with innate and adaptive regulation of the immune system, exemplarily for one protective and one harmful environmental factor, respectively.
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