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Application of metagenomic next-generation sequencing in the diagnosis of urinary tract infection in patients undergoing cutaneous ureterostomy
Summary
Researchers applied metagenomic next-generation sequencing alongside urine culture to diagnose urinary tract infections in patients with cutaneous ureterostomy. The study found that combining these methods provides more comprehensive diagnostic information, and identified specific cytokines and microorganisms as promising biomarkers for building effective diagnostic models for this patient population.
mNGS, along with urine culture, will provide comprehensive and efficient reference for the diagnosis of UTI in patients with CU and allow us to monitor microbial changes in urine of these patients. Moreover, cytokines (IL-6, IL-1β, and IFN-a) or microorganisms like C. freundii, K. oxytoca or E. cloacae are promising biomarkers for building effective UTI diagnostic model of patients with CU and seriously the VFs and ARGs abundance increase in infected group may play bad effect on clinical treatment.
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