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PFOS Induces Lipometabolism Change, Immune Defense, and Endocrine Disorders in Black-Spotted Frogs: Application of Transcriptome Profiling
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Researchers used transcriptome profiling to show that PFOS exposure in black-spotted frogs disrupted lipid metabolism, immune defense, and endocrine function, identifying PPAR as a molecular initiating event and proposing an adverse outcome pathway for this persistent pollutant.
Amphibian population declines are closely linked to increasingly serious environmental pollution. Field investigations revealed that perfluorooctane sulfonic acid (PFOS) distribution was detected in 100% of amphibians. In the present study, global transcriptome sequencing was determined on black-spotted frogs to quantify transcript expression levels and the development of an adverse outcome pathway for PFOS. A total of 1441 differentially expressed genes were identified in the PFOS exposure for 21 d, with 645 being downregulated and 796 upregulated. The gene functions and pathways for lipid metabolism, endocrine system, and immune defense were enriched. An adverse outcome pathway has been proposed, including PPAR (peroxisome proliferator-activated receptors) as the molecular initiating events; followed by changes in lipid metabolism, endocrine system, and immune defense; with an end result of liver damage or even population decline. This research provides molecular insight into the toxicity of PFOS. More research about differentially expressed genes is warranted to further provide the underlying mechanism that is altered as a result of PFOS toxicity in organisms.
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