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Evaluation of a chronic exposure to nanoplastics in goldfish (Carassius auratus): Analytical validation of automated assays for the measurement of biochemical markers

Ecological Indicators 2023 12 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

I. Brandts, I. Brandts, Mariana Teles, I. Brandts, Mariana Teles, M. Blonç, M. Blonç, M. Blonç, Lorena Franco‐Martínez, M. Blonç, M. Blonç, M. Blonç, I. Brandts, I. Brandts, I. Brandts, I. Brandts, I. Brandts, I. Brandts, I. Brandts, I. Brandts, M. Cánovas, I. Brandts, I. Brandts, I. Brandts, Asta Tvarijonaviciute, Mariana Teles, Carlos Gravato Carlos Gravato I. Brandts, Mariana Teles, M. Cánovas, I. Brandts, I. Brandts, I. Brandts, I. Brandts, M. Cánovas, M. Cánovas, Carlos Gravato Lluís Tort, Asta Tvarijonaviciute, Asta Tvarijonaviciute, Lluís Tort, Asta Tvarijonaviciute, I. Brandts, Carlos Gravato Asta Tvarijonaviciute, Carlos Gravato Mariana Teles, Asta Tvarijonaviciute, Asta Tvarijonaviciute, Asta Tvarijonaviciute, Lorena Franco‐Martínez, Lorena Franco‐Martínez, Lorena Franco‐Martínez, Camila Peres Rubio, Mariana Teles, Lorena Franco‐Martínez, Lluís Tort, Carlos Gravato Carlos Gravato Carlos Gravato Carlos Gravato Asta Tvarijonaviciute, Asta Tvarijonaviciute, Lluís Tort, I. Brandts, Lluís Tort, Mariana Teles, Carlos Gravato Mariana Teles, Mariana Teles, Asta Tvarijonaviciute, Asta Tvarijonaviciute, Mariana Teles, Asta Tvarijonaviciute, Mariana Teles, Mariana Teles, Lluís Tort, Lluís Tort, Asta Tvarijonaviciute, Carlos Gravato Lluís Tort, Carlos Gravato Lluís Tort, Lluís Tort, Carlos Gravato Carlos Gravato Asta Tvarijonaviciute, Mariana Teles, Mariana Teles, Lluís Tort, Lluís Tort, Mariana Teles, Mariana Teles, Lluís Tort, Carlos Gravato Asta Tvarijonaviciute, Carlos Gravato Mariana Teles, Carlos Gravato Carlos Gravato Mariana Teles, Mariana Teles, Mariana Teles, Mariana Teles, Carlos Gravato Mariana Teles, Lluís Tort, Carlos Gravato Mariana Teles, Mariana Teles, Mariana Teles, Mariana Teles, Carlos Gravato Carlos Gravato

Summary

Researchers exposed goldfish to polystyrene nanoplastics for 30 days to study chronic effects on health biomarkers in gills, brain, and muscle. They found that nanoplastics primarily triggered immune and antioxidant stress responses in the gills — the fish's first point of contact — but caused no measurable effects in muscle, suggesting gills may be an early warning site for plastic particle toxicity in fish.

The bulk of plastic pollution is mainly composed of small fragments, micro- and nanoplastics (NPs). Although many studies are currently published on NPs, research on the effects of NPs in fish after a chronic exposure is still scarce. The present study aimed to validate a series of automated assays to be used in the monitoring of fish challenged with a chronic exposure to NPs, using Carassius auratus (goldfish) as model species. For this purpose, adult C. auratus were exposed to 100 µg/L polystyrene (PS)-NPs for a 30-day period. Total oxidative status (TOS), total antioxidant capacity (TAC), esterase activity (EA) and adenosine deaminase activity (ADA) were measured in the gills, brain and muscle of fish. In addition, acetylcholinesterase activity (AChE) and creatinine kinase (CK) were measured in the muscle. All biomarkers were successfully validated in goldfish tissues and consequently used to assess the effects of NPs following a chronic exposure. Results showed that EA and TAC significantly increased in gills, while EA decreased significantly in the brain, and no effects were observed in any of these parameters in muscle. These results indicate that both immune and antioxidant responses were triggered by NPs in gills, but not in the brain nor muscle. This suggests that gills may be a primary target for NPs, potentially leading to a cascading effect on gas exchange, or osmo- and ionic regulation that should be further investigated.

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