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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Gut & Microbiome Human Health Effects Policy & Risk Remediation Sign in to save

Impact of Microplastics on the Ocular Surface

International Journal of Molecular Sciences 2023 35 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Duoduo Wu, Blanche Xiao Hong Lim, Ivan Seah, Shay Xie, Julia E. Jaeger, Robert Symons, Amy L. Heffernan, Emily Curren, Sandric Chee Yew Leong, Andri K. Riau, Dawn Lim, Fiona Stapleton, Mohammad Javed Ali, Swati Singh, Louis Tong, Jodhbir S. Mehta, Xinyi Su, Chris Hong Long Lim

Summary

This review examines emerging evidence on how microplastics may affect the surface of the human eye. Researchers found that microplastics can potentially trigger inflammatory responses, microbial imbalance, and oxidative stress in ocular tissues, though research is still limited. The study highlights the need for more investigation into this overlooked exposure route, as the eyes are constantly exposed to airborne particles including microplastics.

Body Systems

Plastics are synthetic materials made from organic polymers that are ubiquitous in daily living and are especially important in the healthcare setting. However, recent advances have revealed the pervasive nature of microplastics, which are formed by degradation of existing plastic products. Although the impact on human health has yet to be fully characterised, there is increasing evidence that microplastics can trigger inflammatory damage, microbial dysbiosis, and oxidative stress in humans. Although there are limited studies investigating their effect on the ocular surface, studies of microplastics on other organs provide some insights. The prevalence of plastic waste has also triggered public outcry, culminating in the development of legislation aimed at reducing microplastics in commercial products. We present a review outlining the possible sources of microplastics leading to ocular exposure, and analyse the possible mechanisms of ocular surface damage. Finally, we examine the utility and consequences of current legislation surrounding microplastic regulation.

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