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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Detection Methods Human Health Effects Nanoplastics Sign in to save

Enhancement of biological effects of oxidised nano- and microplastics in human professional phagocytes

Environmental Toxicology and Pharmacology 2023 25 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
A. Laganà, Giuseppa Visalli, A. Laganà, Alessio Facciolà, A. Laganà, A. Laganà, Giuseppa Visalli, A. Laganà, Giuseppa Visalli, Giuseppa Visalli, A. Laganà, Alessio Facciolà, Consuelo Celesti, Giuseppa Visalli, Giuseppa Visalli, Alessio Facciolà, Daniela Iannazzo, Giuseppa Visalli, Alessio Facciolà, Alessio Facciolà, Alessio Facciolà, Consuelo Celesti, Alessio Facciolà, Alessio Facciolà, Consuelo Celesti, Angela Di Pietro Antonella Iaconis, Jessica Curcio, Alessio Facciolà, Daniela Iannazzo, Jessica Curcio, Daniela Iannazzo, Giuseppa Visalli, A. Laganà, Angela Di Pietro Angela Di Pietro Angela Di Pietro Santa Pollino, Santa Pollino, Consuelo Celesti, Consuelo Celesti, Angela Di Pietro Silvia Scalese, Daniela Iannazzo, Sebania Libertino, Angela Di Pietro Daniela Iannazzo, Angela Di Pietro

Summary

Researchers studied how virgin and environmentally aged polystyrene nano- and microplastics affect human immune cells (monocytes and macrophages). The study found that oxidized particles, which simulate environmental aging, caused significantly greater DNA damage and oxidative stress than virgin particles, suggesting that weathered plastics in the environment may pose higher health risks.

Polymers
PS
Body Systems
Immune

Micro and nanoplastics are ubiquitous pollutants that can cause adverse health effects even in humans. Effects of virgin and oxidised (simulating the aging processes) polystyrene nano (nPS) and micro particles (mPS) with diameters of 0.1 and 1 µm were studied on human professional phagocytes (i.e., monocyte cells THP-1 and macrophage-like mTHP-1 cells). After characterization by ATR-FTIR, UV-Vis spectroscopy, SEM and dynamic light-scattering analyses, the particles were FITC functionalised to quantify cellular uptake. Changes in the cell compartments were studied by acrydine orange and the pro-oxidant, cytotoxic and genotoxic effects were assessed. Phagocytosis was dose- and time- dependent and at 24 h 52% of nPS and 58% of mPS were engulfed. Despite the high homeostasis of professional phagocytes, significant ROS increases and DNA damage were observed after exposure to oxidised particles. The results highlight that the environmental aging processes enhances the adverse health effects of micro and nanoplastics.

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