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Effect of aging of microplastics on gene expression levels of the marine mussel Mytilus edulis: Comparison in vitro/in vivo exposures

Marine Pollution Bulletin 2023 19 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 55 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Coraline Roman, Rihab Jaouani, Fabienne Lagarde, Rihab Jaouani, Fabienne Lagarde, Coraline Roman, Rihab Jaouani, Rihab Jaouani, Amélie Châtel Amélie Châtel Fabienne Lagarde, Amélie Châtel Amélie Châtel Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Fabienne Lagarde, Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Coraline Roman, Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Justine Decaix, Amélie Châtel Amélie Châtel Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Coraline Roman, Coraline Roman, Justine Decaix, Coraline Roman, Coraline Roman, Coraline Roman, Coraline Roman, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Coraline Roman, Fabienne Lagarde, Coraline Roman, Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Amélie Châtel Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Amélie Châtel Amélie Châtel Amélie Châtel Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Amélie Châtel Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Amélie Châtel Amélie Châtel Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel Amélie Châtel Amélie Châtel Amélie Châtel Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Amélie Châtel Fabienne Lagarde, Fabienne Lagarde, Amélie Châtel

Summary

Researchers compared the effects of aged versus non-aged polyethylene microplastics on the marine mussel Mytilus edulis using both in vitro and in vivo exposures at environmentally relevant concentrations. The study found that gene expression changes in xenobiotic defense, immune function, and cell cycle control differed depending on whether the plastic was aged and the type of exposure method used. These findings highlight that the environmental weathering state of microplastics is an important factor in determining their biological effects on marine organisms.

Polymers

Body Systems

Immune

Models

Invertebrate other

Study Type In vivo

In the present study, effects of aging MPs of polyethylene (PE) were investigated in the marine mussel Mytilus edulis, commonly used as bioindicator of aquatic ecosystem, using both in vitro and in vivo exposures, using concentrations found in marine waters (0.008, 10 and 100 μg.L). Changes in gene expression levels implicated in detoxification, immune system, cytoskeletton and cell cycle control were evaluated by quantitative RT-qPCR. Results demonstrated differential expression levels depending upon the state of plastic degradation (aged vs non-aged) and way of exposure (vitro vs vivo). This study highlighted the interest of using molecular biomarkers based on analysis of gene expression pattern in an ecotoxicological context that gives indication of relative slight changes between tested conditions as compared to other biochemical approaches (e.g. enzymatic activities). In addition, in vitro analysis could be used to generate large amount of data as regards to the toxicological effects of MPs.

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