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Article
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AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button.
Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Nanoplastics
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Polystyrene nanoplastics lead to ferroptosis in the lungs
Journal of Advanced Research
2023
92 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Yuhao Wu,
Junke Wang,
Tianxin Zhao,
Mang Sun,
Maozhu Xu,
Siyi Che,
Zhengxia Pan,
Wu Chun,
Lianju Shen,
Lianju Shen
Summary
Researchers found that polystyrene nanoplastics trigger ferroptosis — a type of iron-driven cell death — in the cells lining the lungs by activating a stress signaling pathway (HIF-1α/HO-1), ultimately causing lung tissue injury. This adds to growing evidence that inhaled nanoplastics can directly damage respiratory tissue through oxidative cell death mechanisms.
Polymers
Body Systems
PS-NP exposure caused ferroptosis in bronchial epithelial cells by activating the HIF-1α/HO-1 signaling pathway, and eventually led to lung injury.