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Polystyrene nanoplastics lead to ferroptosis in the lungs

Journal of Advanced Research 2023 92 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Tianxin Zhao Yuhao Wu, Lianju Shen, Lianju Shen, Junke Wang, Tianxin Zhao Tianxin Zhao Mang Sun, Mang Sun, Tianxin Zhao Maozhu Xu, Siyi Che, Siyi Che, Zhengxia Pan, Junke Wang, Yuhao Wu, Wu Chun, Lianju Shen, Lianju Shen, Lianju Shen, Lianju Shen, Lianju Shen, Tianxin Zhao

Summary

Researchers found that polystyrene nanoplastics trigger ferroptosis — a type of iron-driven cell death — in the cells lining the lungs by activating a stress signaling pathway (HIF-1α/HO-1), ultimately causing lung tissue injury. This adds to growing evidence that inhaled nanoplastics can directly damage respiratory tissue through oxidative cell death mechanisms.

PS-NP exposure caused ferroptosis in bronchial epithelial cells by activating the HIF-1α/HO-1 signaling pathway, and eventually led to lung injury.

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