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Nanoplastics
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Effects of true-to-life PET nanoplastics using primary human nasal epithelial cells
Environmental Toxicology and Pharmacology2023
55 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 60
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Balasubramanyam Annangi,
Balasubramanyam Annangi,
Alireza Tavakolpournegari,
Alireza Tavakolpournegari,
Alireza Tavakolpournegari,
Lourdes Vela,
Ricard Marcos,
Aliro Villacorta
Alba Hernández,
Aliro Villacorta
Alba Hernández,
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Alba Hernández,
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Ricard Marcos,
Ricard Marcos,
Lourdes Vela,
Balasubramanyam Annangi,
Balasubramanyam Annangi,
Alba Hernández,
Aliro Villacorta
Alireza Tavakolpournegari,
Alireza Tavakolpournegari,
Lourdes Vela,
Alba Hernández,
Lourdes Vela,
Lourdes Vela,
Aliro Villacorta
Aliro Villacorta
Aliro Villacorta
Alba Hernández,
Ricard Marcos,
Alba Hernández,
Alireza Tavakolpournegari,
Alba Hernández,
Alba Hernández,
Ricard Marcos,
Alba Hernández,
Ricard Marcos,
Alba Hernández,
Ricard Marcos,
Ricard Marcos,
Alba Hernández,
Alba Hernández,
Aliro Villacorta
Alba Hernández,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Lourdes Vela,
Alba Hernández,
Alba Hernández,
Aliro Villacorta
Alba Hernández,
Alba Hernández,
Aliro Villacorta
Alba Hernández,
Alba Hernández,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Alireza Tavakolpournegari,
Ricard Marcos,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Ricard Marcos,
Alba Hernández,
Ricard Marcos,
Alba Hernández,
Ricard Marcos,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Aliro Villacorta
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Alba Hernández,
Alba Hernández,
Ricard Marcos,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Ricard Marcos,
Ricard Marcos,
Ricard Marcos,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Ricard Marcos,
Alba Hernández,
Ricard Marcos,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Ricard Marcos,
Ricard Marcos,
Alba Hernández,
Ricard Marcos,
Ricard Marcos,
Alba Hernández,
Balasubramanyam Annangi,
Balasubramanyam Annangi,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Alba Hernández,
Ricard Marcos,
Ricard Marcos,
Alba Hernández,
Alba Hernández,
Aliro Villacorta
Summary
Researchers exposed human nasal cells to nanoplastics made from real PET water bottles and found that the particles were absorbed into cells and triggered oxidative stress. The nanoplastics also disrupted mitochondrial function and activated the cell's autophagy cleanup pathway. Since the nose is the first barrier encountered when breathing in airborne plastic particles, these findings suggest that nasal tissues may be particularly vulnerable to nanoplastic exposure.
Since inhalation is a relevant exposure route, studies using appropriate micro/nanoplastic (MNPLs) models, representative targeted cells, and relevant biomarkers of effect are required. We have used lab-made polyethylene terephthalate (PET)NPLs obtained from PET plastic water bottles. Human primary nasal epithelial cells (HNEpCs) were used as a model of the first barrier of the respiratory system. Cell internalization and intracellular reactive oxygen species (iROS) induction, as well as the effects on mitochondria functionality and in the modulation of the autophagy pathway, were evaluated. The data indicated significant cellular uptake and increased levels of iROS. Furthermore, a loss of mitochondrial membrane potential was observed in the exposed cells. Regarding the effects on the autophagy pathway, PETNPLs exposure significantly increases LC3-II protein expression levels. PETNPLs exposure also induced significant increases in the expression of p62. This is the first study showing that true-to-life PETNPLs can alter the autophagy pathway in HNEpCs.