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Di-(2-ethylhexyl) phthalate and its Metabolites Research Trend: A Bibliometric Analysis
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This bibliometric analysis maps 47 years of research into DEHP, a plasticizer widely used in PVC plastics, identifying its endocrine-disrupting and reproductive effects as major concerns and noting that microplastics are an emerging research trend in this field. DEHP is relevant to microplastic health risks because plastic particles can carry DEHP as a chemical contaminant, releasing it into the body upon ingestion or inhalation.
Abstract Background:Di-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used plasticizers.Many studies focus on the impact of continuous exposure to DEHP on humans and ecosystems.In this study, the bibliometric analysis of DEHP and its metabolites research was conducted to assess the research performances, hotspot issues, and trends in this field. Method:The data was retrieved from a web of science core collection online database.VOSviewer 1.6.18 was used to analyze. Result:A total of 4672 publications were retrieved from 1975 to 2022 October 21.The number of publications and citations increased annually in the last decades.China had the largest number of publications and the USA had the highest co-authorship score.The most productive and most frequently cited institutions were the Chinese Academy of Sciences and the Centers for Disease Control & Prevention(USA) , respectively.The journal with the most publications was Science of Total Environment and the most cited one was Environmental Health Perspectives.The most productive and cited author was Calafat AM(USA).The most cited reference was “Phthalates: Toxicology and exposure”.Four hotspot issues were as follows: influences of DEHP on the organisms and its possible mechanisms; assessment of DEHP exposure to the human and its metabolism; dynamics of DEHP in external environments; indoor exposure of DEHP and health outcomes.The research trends were DNOP, preterm birth, gut microbiota, microplastics, lycopene, hypertension, and thyroid hormones. Conclusion:This paper will be a useful resource for researchers to rapidly take the valuable information related to the authoritative scholars, publications, journals and institutions, hotspot issues, and trends in this research field.
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Di-(2-ethylhexyl) phthalate and its metabolites research trend: a bibliometric analysis
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This bibliometric analysis mapped research trends on di-(2-ethylhexyl) phthalate (DEHP) and its metabolites, identifying growth areas, major contributors, and gaps in understanding human exposure, metabolism, and health effects of this common plasticizer.
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Researchers assessed the endocrine-disrupting potential of alternative plasticizers used to replace the commonly restricted DEHP (bis(2-ethylhexyl) phthalate), finding that several substitutes also displayed hormonal activity. The results raise concerns that some replacement plasticizers used in consumer plastics may carry similar health risks as the chemicals they were designed to replace.
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Researchers investigated the presence and fate of microplastics during the wastewater treatment process, along with the plasticizer DEHP associated with them. They found that while treatment stages reduced microplastic numbers, the particles persisted throughout the process, and DEHP was detected in both the microplastics and surrounding wastewater. The study suggests that wastewater treatment plants are a significant pathway through which microplastics and associated chemicals enter the environment.
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