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Potential of Red Seaweed (Dichotomania obtusata) on Immune Response and Histopathology of Rat Testis Exposed to Nanoplastics
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Researchers found that red seaweed (Dichotomania obtusata) extract improved immune response and reduced histopathological damage in rat testes exposed to nanoplastics, suggesting potential protective effects against nanoplastic-induced reproductive toxicity.
Polystyrene nanoplastics (NP) are often found in aquatic environments. The accumulation of nanoplastics in aquatic biota such as fish, shrimp, squid, shellfish, etc. can reduce the health of humans who consume them. The purpose of this study was to observe the red seaweed’s potential as a source of antioxidants in improving the immune system and reproductive health of rats (Rattus novergicus) exposed to nanoplastics. Twenty-five rats (Rattus norvegicus) were divided into five groups with various treatments, namely control, negative control (2 µL/kg BW NP), and three combined treatments of 2 µL/kg BW NP with varying concentrations of seaweed extract (50, 100, and 200 mg/kg BW), were treated to determine levels of TNF-α, IFN-γ, histopathology, size, and weight of the testes. The results showed that exposure to 2 µL/kg BW NP increased levels of cytokines (TNF-α and IFN-γ) and affected the histology and size of the rat testes. Administration of seaweed extract (50, 100, and 200 mg/kg BW) could improve cytokine levels by decreasing IFN-γ and repair rat testicular histology by increasing spermatid number and thickness of seminiferous tubule epithelium.
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Researchers studied whether the plant compound rhamnetin could protect against testicular damage caused by polystyrene microplastics in rats. Microplastic exposure caused significant harm to sperm quality, hormone levels, and testicular tissue through oxidative stress and inflammation. Co-treatment with rhamnetin restored many of these markers, suggesting it may help counteract some of the reproductive harm associated with microplastic exposure.
Toxic Effects of Immunofluorescent Polystyrene Nanoplastics on Rat Testicular Tissue
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Researchers exposed rat testicular tissue to fluorescent polystyrene nanoplastics at two different doses for one month and found that the particles accumulated in the reproductive organs. Higher doses led to increased oxidative stress, tissue damage, and changes in biochemical markers associated with reproductive function. The study suggests that nanoplastic exposure may pose risks to male reproductive health, though more research is needed to understand the implications for humans.
Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological study
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Researchers investigated whether the plant compound chrysoeriol could protect against testicular damage caused by polyethylene microplastics in a rat model. The study found that microplastic exposure reduced antioxidant enzyme activity and increased inflammation markers, while co-administration of chrysoeriol showed a protective effect by mitigating oxidative stress and preserving sperm quality.
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