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Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine
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In mice, 100 nanometer polystyrene nanoplastics caused kidney toxicity through inflammation, oxidative stress and disturbed lipid metabolism. Mice given DHA-enriched phosphatidylserine had lower inflammatory markers and higher antioxidant enzyme activity in the kidney. The authors report this as the first study of the compound in this model.
Nanoplastics (NPs) induce nephrotoxicity in mammals, but an understanding of the potential mechanism or amelioration strategies is lacking. Herein, we established the polystyrene nanoplastics (PS-NPs, 100 nm)-induced nephrotoxicity murine model, and investigated the potential molecular mechanism of docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) alleviating effects. Based on the biochemical indices, H&E staining and kidney metabolomics, we found that PS-NPs did cause murine nephrotoxicity, mainly due to inflammation, oxidative stress, and lipid disturbance. DHA-PS administration alleviated these effects, mainly by decreasing renal levels of IL-6, IL-1β, TNF-α and MDA, increasing the level of IL-10, increasing the activities of SOD, GSH-Px, CAT, and alleviating lipid disturbance, mainly by modulating kidney glycerophospholipid metabolism, linoleic acid metabolism and the SIRT1-AMPK pathway. This is the first time that the amelioration effects of DHA-PS on PS-NPs-induced nephrotoxicity have been investigated from multiple perspectives, providing a potential mechanism of nephrotoxicity caused by PS-NPs.
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This study found that a nutrient derived from marine sources, DHA-enriched phosphatidylserine, could protect mouse livers from damage caused by polystyrene nanoplastics. The nanoplastics disrupted gut bacteria and caused liver inflammation, but the DHA compound helped restore gut health and reduce liver injury. This research suggests that certain dietary supplements might help counteract some of the harmful effects of nanoplastic exposure on the digestive system.
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Researchers found that oral exposure to polystyrene nanoparticles caused significant kidney damage in rats, including oxidative stress, impaired renal function, and tissue alterations that worsened with increasing dose, demonstrating their nephrotoxic potential.
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Researchers demonstrated that 28-day oral exposure to polystyrene nanoplastics in rats caused liver and kidney toxicity—marked by elevated oxidative stress, inflammation, endoplasmic reticulum stress, and histopathological damage—and that co-administration of the antioxidant ellagic acid significantly attenuated these harmful effects.
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