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Large polystyrene microplastics results in hepatic lipotoxicity in mice

Environmental Pollution 2023 14 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 50 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yongfeng Deng, Yongfeng Deng, Yongfeng Deng, Yongfeng Deng, Yongfeng Deng, Yongfeng Deng, Qing Wang Qing Wang Qing Wang Yongfeng Deng, Qing Wang Qing Wang Qing Wang Hexia Chen, Hexia Chen, Z. Liu, Yongfeng Deng, Yongfeng Deng, Yongfeng Deng, Qing Wang Yongfeng Deng, Z. Liu, Hexia Chen, Yongfeng Deng, Z. Liu, Hexia Chen, Hexia Chen, Hongli Tan, Hexia Chen, Da Chen, Qing Wang Hongli Tan, Yongfeng Deng, Hongli Tan, Hexia Chen, Da Chen, Qing Wang Hongli Tan, Qing Wang Yongfeng Deng, Qing Wang Qing Wang Hongli Tan, Yongfeng Deng, Yongfeng Deng, Hexia Chen, Hongli Tan, Hongli Tan, Qing Wang Qing Wang Hongli Tan, Hongli Tan, Z. Liu, Qing Wang Hongli Tan, Wen Chen, Z. Liu, Qing Wang Hongli Tan, Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Yongfeng Deng, Da Chen, Z. Liu, Wen Chen, Da Chen, Qing Wang Yongfeng Deng, Hongli Tan, Qing Wang Qing Wang Qing Wang Da Chen, Qing Wang Hongli Tan, Qing Wang Wen Chen, Qing Wang Hongli Tan, Qing Wang Da Chen, Qing Wang Hongli Tan, Da Chen, Hongli Tan, Hongli Tan, Qing Wang Da Chen, Qing Wang Hongli Tan, Qing Wang Hexia Chen, Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Qing Wang Hongli Tan, Hexia Chen, Wen Chen, Yongfeng Deng, Da Chen, Qing Wang Qing Wang Qing Wang Yongfeng Deng, Qing Wang Qing Wang Qing Wang Da Chen, Qing Wang Qing Wang Qing Wang Da Chen, Wen Chen, Da Chen, Qing Wang Da Chen, Da Chen, Qing Wang

Summary

Researchers found that long-term exposure to large polystyrene microplastics (40-100 micrometers) caused hepatic lipid metabolism disruption and lipotoxicity in mice, demonstrating that even large microplastics that do not accumulate in tissues can still cause significant liver damage.

Polymers

Body Systems

Hepatic

Models

Mouse

Like small microplastics (MPs), recent studies reveal that large MPs could cause health risks in mice, even if they are not enriched in tissues. However, potential hepatoxicity following large MPs exposure and the underlying mechanisms have not been thoroughly investigated. In the present study, we explored the disruption of hepatic lipid metabolism and potential underlying toxic mechanisms in mice caused by long-term exposure to large polystyrene MPs (40-100 μm) based on a multi-omic approach. After 21 weeks of feeding foods containing MPs (50 and 500 mg/kg food), lipidomic revealed that environmentally relevant and higher doses MP exposures resulted in significant changes in a total of 20 lipid classes. Ceramide (Cer) and dihydroceramide (dhCer) were significantly reduced, while cholesteryl ester (CE), lysoalkylphosphatidylcholine (LPCO), lysophosphatidylethanolamine (LPE) and total glyceride (TG) were all elevated by MPs. The transcriptomic and other physiological data suggested that the potential toxic mechanisms may be related to disorders of fatty acid and cholesterol synthesis and metabolism disorders, and transporting of TG. Our findings demonstrate the hepatic lipotoxicity following exposure to environmentally relevant and higher doses of large MPs, calling for future research and management of the environmental risks of MPs with relatively large particle sizes.

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