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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Sign in to save

Long‐Chain Acyl Carnitines Aggravate Polystyrene Nanoplastics‐Induced Atherosclerosis by Upregulating MARCO (Adv. Sci. 19/2023)

Advanced Science 2023
B. L. Wang, Boxuan Liang, Yuji Huang, Yuji Huang, Zhiming Li, Bingli Zhang, Jiaxin Du, Rongyi Ye, Hongyi Xian, Hongyi Xian, Yanhong Deng, Jiancheng Xiu, Xingfen Yang, Sahoko Ichihara, Gaku Ichihara, Yizhou Zhong, Zhenlie Huang

Summary

This is a graphical abstract or cover-image entry for a research article (published in Advanced Science) that found long-chain acyl carnitines — naturally occurring metabolic molecules — make polystyrene nanoplastic-induced atherosclerosis significantly worse by activating a specific receptor (MARCO) on immune cells. The finding suggests that microplastic exposure interacts with the body's own metabolism to amplify cardiovascular disease risk.

Polymers
PS
Body Systems
Cardiovascular Immune

Microplastics and Nanoplastics Qin Qiong is revered as a venerable guardian deity in ancient Chinese mythology. Similarly, macrophages serve as its protectors within the cardiovascular system. In article number 2205876, Yizhou Zhong, Zhenlie Huang, and co‐workers unveil that when the cardiovascular system is exposed to micro‐ and nanoplastics (MNPs), macrophages face not only the direct assault from the MNPs but also simultaneous aggression from long‐chain acylcarnitines, a kind of endogenous chemical compound. These findings have the potential to aid in managing the escalating health risks imposed on humanity by increasing MNP exposure. [Image: see text]

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