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Human Health Effects
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The synergetic effects of 4-nonylphenol and polyethylene microplastics in Cyprinus carpio juveniles using blood biomarkers
Scientific Reports2023
11 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 50
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Esraa E. Ammar,
Esraa E. Ammar,
Mohamed Hamed,
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Mohamed Hamed,
Mohamed Hamed,
Mohamed Hamed,
Mohamed Hamed,
Mohamed Hamed,
Mohamed Hamed,
Alaa El‐Din H. Sayed
Mohamed Hamed,
Mohamed Hamed,
Mohamed Hamed,
Mohamed Hamed,
Alaa El‐Din H. Sayed
Mohamed Hamed,
Mahmoud S. Mohamed,
Mahmoud S. Mohamed,
Mohamed Hamed,
Alaa El‐Din H. Sayed
Mohamed Hamed,
Mohamed Hamed,
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Mohamed Hamed,
Alaa El‐Din H. Sayed
Mohamed Hamed,
Mohamed Hamed,
Mohamed Hamed,
Mohamed Hamed,
Mohamed Hamed,
Mahmoud S. Mohamed,
Mahmoud S. Mohamed,
Mahmoud S. Mohamed,
Mohamed Hamed,
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Mohamed Hamed,
Mahmoud S. Mohamed,
Mahmoud S. Mohamed,
Mahmoud S. Mohamed,
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Mohamed Hamed,
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Alaa El‐Din H. Sayed
Summary
Researchers found that polyethylene microplastics and the endocrine disruptor 4-nonylphenol produce synergistic toxic effects in juvenile carp, with combined exposure causing greater disruption to blood biomarkers than either contaminant alone.
Microplastics are widely distributed in aquatic ecosystems along with other chemical pollutants. Therefore, it is vital to study the health-hazardous effects of MPs in combination with 4-nonylphenol (4-NP), which is a highly abundant industrial waste and a critical alkylphenol endocrine disruptor. We investigated the effects of the exposure to polyethylene microplastics (PE-MPs), 4-NP, and their combination on blood biomarkers in Cyprinus carpio juveniles. Four study groups were treated for 15 consecutive days: (1) control group, (2) 10 mg/L PE-MP group, (3) 10 mg/L PE-MPs + 200 µg/L 4-NP group, and (4) 200 µg/L 4-NP group, followed by 15 days of recovery. Biochemical analyses showed that creatine kinase, lactate dehydrogenase, glucose, liver enzymes, total protein, and A/G ratios were significantly increased after exposure to PE-MPs, 4-NP, and the combination. Hematological parameters (RBC's, Hb, Ht, neutrophil percentage, and WBC's) were significantly decreased in the three exposure groups, whereas mean corpuscular volume and lymphocyte percentages were significantly increased. The 15-day recovery period improved most hematobiochemical parameters and PE-MP accumulation indices. Taken together, we demonstrated the hazardous effects of PE-MP and 4-NP combinations on C. carpio blood parameters and highlighted their potential risk to human health.