We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua)
AI summary Read the abstract
Researchers exposed juvenile Atlantic cod to dietary mixtures of chlorinated, brominated, and fluorinated persistent organic pollutants at environmentally relevant concentrations for four weeks, finding that all three compound classes activated the unfolded protein response (UPR) in the liver. The UPR was identified as a shared stress pathway for diverse classes of halogenated pollutants, with combined mixture exposure producing additive or synergistic effects.
In the North Sea and North Atlantic coastal areas, fish experience relatively high background levels of persistent organic pollutants. This study aimed to compare the mode of action of environmentally relevant concentrations of mixtures of halogenated compounds in Atlantic cod. Juvenile male cod with mean weight of 840 g were exposed by gavage to dietary mixtures of chlorinated (PCBs, DDT analogs, chlordane, lindane, and toxaphene), brominated (PBDEs), and fluorinated (PFOS) compounds for 4 weeks. One group received a combined mixture of all three compound groups. The results showed that the accumulated levels of chemicals in cod liver after 4 weeks of exposure reflected concentrations found in wild fish in this region. Pathway analysis revealed that the treatment effects by each of the three groups of chemicals (chlorinated, brominated, and fluorinated) converged on activation of the unfolded protein response (UPR). Upstream regulator analysis predicted that almost all the key transcription factors (XBP1, ERN1, ATF4, EIF2AK3, and NFE2L2) regulating the UPR were significantly activated. No additive effect was observed in cod co-treated with all three compound groups. In conclusion, the genome-wide transcriptomic study suggests that the UPR pathway is a sensitive common target of halogenated organic environmental pollutants in fish.
More Papers Like This
Polybrominated diphenyl ethers as hitchhikers on microplastics: Sorption behaviors and combined toxicities to Epinephelus moara
AI summary Read the abstract
Researchers investigated how microplastics carry polybrominated diphenyl ethers (PBDEs) and found that combined exposure caused more severe oxidative stress and gene expression changes in grouper fish than either pollutant alone.
The influence of microplastics and halogenated contaminants in feed on toxicokinetics and gene expression in European seabass (Dicentrarchus labrax)
AI summary Read the abstract
Researchers studied how microplastics and halogenated contaminants in fish feed affected the toxicokinetics of those contaminants, finding that microplastics in feed altered how persistent organic pollutants were absorbed and distributed in fish tissues.
The impact of combined exposure to triphenyltin and microplastics on the oxidative stress, energy metabolism, and digestive function of common carp (Cyprinus carpio)
AI summary Read the abstract
Exposing common carp to triphenyltin and microplastics individually and in combination found that combined exposure caused greater oxidative stress, disrupted energy metabolism more severely, and more strongly impaired digestive enzyme activity than either pollutant alone.
PCB-126 spiked to polyethylene microplastic ingested by juvenile Atlantic cod (Gadus morhua) accumulates in liver and muscle tissues
AI summary Read the abstract
Researchers found that PCB-126 spiked onto polyethylene microplastics accumulated in the liver and muscle tissues of juvenile Atlantic cod, while even virgin microplastics impaired skin barrier function, suggesting gut-mediated effects on fish health.
Physiological and transcriptomic responses of seawater halobios to micro/nano-scale polystyrene-cadmium exposure in a marine food web.
AI summary Read the abstract
Using a marine food web model with algae, shrimp, and fish, researchers showed that combined polystyrene microplastic and cadmium exposure caused greater physiological harm than either pollutant alone, with toxicity and bioaccumulation amplified at each trophic level.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.