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Transcriptomic analysis of oxidative stress mechanisms induced by acute nanoplastic exposure in Sepia esculenta larvae
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Researchers used transcriptomic analysis to reveal that acute nanoplastic exposure in cuttlefish larvae triggered oxidative stress through disruption of antioxidant enzyme gene expression, identifying key molecular pathways affected by plastic pollution in marine cephalopods.
Nanoplastics (NPs), as a new type of pollutant with a size small than 1 μm, are ubiquitous and harmful to organisms. There has been an increasing amount of research concerning the effects of NPs on organisms over recent years, especially on aquatic animals. However, there is a limited study on the impact of NPs on mollusk cephalopods. In this research, Sepia esculenta, belonging to Cephalopoda, Coleoidea, Sepioidea, was selected to explore the effects caused by NPs exposure. The S. esculenta larvae were exposed to polystyrene NPs (PS-NPs) with diameter 50 nm (100 mg/L) for 4 h. The detection of oxidative stress biomarkers displayed an obvious increase in SOD (superoxide dismutase) activity and MDA (malondialdehyde) level. Then, RNA-Seq was performed to explore the oxidative stress response at mRNA level. The transcriptome analysis demonstrated that the expression of 2,570 genes was affected by PS-NPs. Besides, the signaling pathways of ribosome, ribosome biogenesis in eukaryotes, proteasome, and MAPK were enriched. This study not only provides novel references for understanding the mechanisms of oxidative stress response induced by NPs, but also reminds us to follow with interest the influence of acute exposure to NPs.
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Acute exposure to polystyrene nanoplastics induced oxidative stress in Sepia esculenta Larvae
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Researchers exposed cuttlefish larvae (Sepia esculenta) to polystyrene nanoplastics and found significant oxidative stress — a type of cellular damage caused by unstable molecules called free radicals — along with changes in the expression of genes involved in stress response pathways. This study extends understanding of nanoplastic harm beyond commonly studied species to economically important marine cephalopods.
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Researchers found that nanoplastics disrupted energy metabolism in juvenile cuttlefish, a popular seafood in China, by suppressing normal energy production pathways and causing oxidative stress. The study used advanced genetic analysis to show how nanoplastics reprogram the way these animals process energy at the molecular level. Since cuttlefish are widely consumed, these effects raise questions about seafood safety in nanoplastic-contaminated waters.
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Researchers found that nanoplastics are more toxic than microplastics in mussels, causing severe inflammatory responses and greater oxidative stress, with transcriptomic analysis revealing contrasting gene expression patterns between the two particle sizes.
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Researchers exposed whiteleg shrimp (Penaeus vannamei) to microplastics for 96 hours and used transcriptomics to profile gene expression changes, finding significant upregulation of stress response, immune, and detoxification pathways, indicating that even short-term microplastic exposure triggers a broad molecular stress response.
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