Article
?
AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button.
Tier 2
?
Original research — experimental, observational, or case-control study. Direct primary evidence.
Nanoplastics
Sign in to save
Interaction of antidiabetic formulation with nanoplastics and its binary influence on plasma protein
Environmental Toxicology and Pharmacology2023
12 citations
?
Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 50
?
0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Rinku Polachirakkal Varghese,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Durgalakshmi Rajendran,
Natarajan Chandrasekaran
Rinku Polachirakkal Varghese,
Natarajan Chandrasekaran
Murugesh Shivashankar,
Natarajan Chandrasekaran
Natarajan Chandrasekaran
C. George Priya Doss,
Natarajan Chandrasekaran
C. George Priya Doss,
C. George Priya Doss,
C. George Priya Doss,
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
C. George Priya Doss,
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
C. George Priya Doss,
Natarajan Chandrasekaran
C. George Priya Doss,
Natarajan Chandrasekaran
C. George Priya Doss,
Murugesh Shivashankar,
C. George Priya Doss,
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
C. George Priya Doss,
C. George Priya Doss,
C. George Priya Doss,
C. George Priya Doss,
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
C. George Priya Doss,
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Natarajan Chandrasekaran
Summary
Researchers investigated how polystyrene nanoplastics interact with the antidiabetic drug metformin and how this combination affects binding to the human blood protein albumin. The study suggests that when metformin coats nanoplastic surfaces, it reduces the particles' affinity for albumin, potentially allowing nanoplastics to reach target organs and interfere with normal drug mechanisms in the body.
Nanoplastics exposure to humans becomes inevitable due to its prevalence and permanence. Adsorption of emerging pollutant metformin hydrochloride (Met-HCl) -antidiabetic drug, on polystyrene nanoplastics (PSNPs) and influence on plasma protein binding was investigated. Fluorescence studies were carried out for human serum albumin (HSA) binding. Adsorption follows pseudo-second-order kinetics, intraparticle-diffusion, and Langmuir isotherm, undergoing both physisorption and chemisorption which was validated by FE-SEM, FTIR, and HRMS measurements. Complex, experiences static quenching mechanism by hydrogen bonding and VanderWaals force of attraction to HSA. FTIR confirms the secondary structural alteration of HSA. Since Met-HCl covers the NPs' surface, NPs' affinity for HSA is reduced and they might reach the target organs of Met-HCl, disrupt antidiabetic mechanisms and cause far-reaching implications. Results from molecular docking and simulation studies backed up these results as hydrophobic and hydrogen bonds dominate the binding process of the HSA-Met-HCl-PSNPs complex. This work will aid in understanding of the toxico-kinetics/dynamics of binary contaminants.