We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Potential genotoxicity impacts of a co-exposure of polypropylene microplastic and antibiotics to freshwater pearl mussel Hyriopsis cumingii (Lea, 1852)
Summary
Researchers assessed the genotoxic effects of combined polypropylene microplastic and antibiotic (sulfamethoxazole and oxytetracycline) exposure in freshwater pearl mussels. Co-exposure produced greater DNA damage and oxidative stress than either contaminant alone, indicating synergistic genotoxicity in this commercially important species.
Microplastics (MPs) are becoming ubiquitous, and their environmental fate is becoming an issue concern. MPs can adsorb antibiotics to coexist and accumulate in the aquatic environment in the form of complexes, resulting in unforeseeable adverse consequences. Herein, we investigated the genotoxic effects of coexist of polypropylene (PP) microplastic and two antibiotics of sulfamethoxazole (SMX) and oxytetracycline (OTC) at environmental concentrations on gill and gastrointestinal tract (GIT) cells of freshwater pearl mussel Hyriopsis cumingii. Results showed that coexist of PP and antibiotics SMX and OTC at environmental concentrations can cause the DNA damage (5.0 – 8.7% in gill and 4.5 7.9 % in GIT) and micronucleus (10.8 – 20.9 ‰ in gill and 11.9 – 18.6 ‰ in GIT) for H. cumingii. By principal component analysis, we found that there was a strong relationship between microplastic accumulation in the GIT and biomarkers, including DNA damage and micronucleus, for H. cumingii co-exposed to PP microplatics in combination with only OTC antibiotic. Meanwhile, only a strong correlation was detected between microplatic accumulation in gill or GIT and DNA damage in those tisues, when H. cumingii was exposed to mixing anibiotics OTC and SMX along with PP microplastic. Our study contributed to improve the understanding of the adverse genetic impacts of coexistance of PP microplastics and antibiotics (SMX and OTC) in the environment as well as to provided essential information for ecological risk assessment of MPs and antibiotics pollution.
Sign in to start a discussion.
More Papers Like This
Combined toxic effects of nanoplastics and norfloxacin on antioxidant and immune genes in mussels
Researchers studied the combined toxic effects of polystyrene nanoplastics and the antibiotic norfloxacin on mussels, focusing on genes related to antioxidant defense and immune function. They found that the mixture of both contaminants produced more severe disruptions to gene expression than either substance alone, indicating a synergistic toxic effect. The study suggests that the co-occurrence of nanoplastics and antibiotics in marine environments may pose compounding risks to shellfish health.
Microplastics aggravate the bioaccumulation of three veterinary antibiotics in the thick shell mussel Mytilus coruscus and induce synergistic immunotoxic effects
Researchers studied how polystyrene microplastics interact with three common veterinary antibiotics in thick shell mussels. The study found that when microplastics and antibiotics were present together, mussels accumulated significantly more antibiotics in their tissues and suffered worse immune damage than from either pollutant alone. This synergistic effect included reduced immune cell counts, increased oxidative stress, and disrupted immune gene expression, suggesting that microplastic pollution may amplify the harmful effects of antibiotic contamination in coastal waters.
Co-exposure to Microplastics and Cadmium: Effects on DNA Damage in Mytilus Galloprovincialis
This study investigated how co-exposure to microplastics and cadmium affects DNA damage in the Mediterranean mussel Mytilus galloprovincialis. Microplastics acted as vectors for cadmium, and combined exposure resulted in greater genotoxic effects than either pollutant alone.
Multilevel toxicity assessment of polypropylene microplastics and pyrene on mussels: DNA damage, oxidative stress, and physiological effects
Mussels were exposed to polypropylene microplastics and pyrene individually and together, revealing that DNA damage paradoxically decreased under co-exposure, suggesting complex antagonistic interactions between these two common marine pollutants.
Multilevel toxicity assessment of polypropylene microplastics and pyrene on mussels: DNA damage, oxidative stress, and physiological effects
An integrative study exposed Mediterranean mussels to polypropylene microplastics and pyrene for 7 and 14 days, finding combined exposure caused greater DNA damage, oxidative stress, and physiological impairment than either pollutant alone in heavily polluted coastal conditions.