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Near-Infrared-II In Vivo Visualization and Quantitative Tracking of Micro/Nanoplastics in Fish
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Scientists developed a new near-infrared imaging technique to track micro- and nanoplastics inside living zebrafish in real time, overcoming limitations of previous detection methods. They found that both sizes of plastic particles accumulated mainly in the gut, with microplastics concentrating more in the front sections and nanoplastics distributing more evenly. This tracking tool helps researchers better understand how plastic particles move through and accumulate in living organisms, which is essential for assessing the risks of microplastic exposure.
As emerging contaminants, micro/nanoplastics (MNPs) are widely present in aquatic environments and are often ingested by aquatic organisms. However, the in vivo trafficking and fate of MNPs remain largely unknown. Here, we developed near-infrared (NIR) aggregated-induced emission (AIE) fluorophore-labeled microplastics (2 μm) and nanoplastics (100 nm) as models of MNPs. This model was based on the NIR-AIE technique with strong emission at the second near-infrared (NIR-IIII) window, which overcomes the interference of autofluorescence and observation artifacts in the detection of commercial fluorescent-labeled particles. Due to its deep tissue penetration and noninvasiveness, the dynamic process of accumulation and transport of MNPs in individuals can be tracked with NIR imaging. We then directly visualized and quantified the uptake and depuration processes of MPs and NPs in zebrafish. The results showed that the MPs and NPs were mainly accumulated in the fish gut, and the distribution was heterogeneous. MPs tended to accumulate more in the fore and mid areas of the gut compared with NPs. Besides, both MPs and NPs could accumulate in large quantities locally in the gut and might cause intestinal obstruction. MNPs accumulated slowly during the initial exposure followed by rapid and sustained accumulation in gut. Based on these kinetic accumulation and depuration, we developed a refined toxicokinetic (TK) model to describe the dynamic changes in the uptake and depuration of MNPs. Overall, this study proposed a MNP model based on the NIR-AIE technique, which provided a reliable tracer technology for the visualization, tracking and quantification of MNPs in vivo.
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