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619P Single-cell and bulk RNA-seq analyses decode the renal microenvironment induced by polystyrene microplastics in mice receiving high-fat diet
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Additional file 1 of Single-cell RNA-seq analysis decodes the kidney microenvironment induced by polystyrene microplastics in mice receiving a high-fat diet
Researchers used single-cell RNA sequencing to decode kidney microenvironmental changes induced by polystyrene microplastics in mice fed a high-fat diet, characterizing mural cell and mesangial cell heterogeneity, DEG profiles, and pathway enrichment in affected renal tissue.
Single-cell RNA-seq analysis decodes the kidney microenvironment induced by polystyrene microplastics in mice receiving a high-fat diet
Using advanced single-cell gene analysis, researchers found that mice fed both polystyrene microplastics and a high-fat diet suffered significantly worse kidney damage than either exposure alone. The combination reshaped the kidney's cellular environment, promoting scarring, triggering cancer-related pathways, and altering immune cell populations. This is particularly relevant to human health because many people are simultaneously exposed to microplastics through food and drink while also consuming high-fat diets.
Single‐Cell Transcriptomic Analysis Reveals Hair Cell‐Specific Molecular Responses to Polystyrene Nanoplastics in a Zebrafish Embryo Model
Researchers exposed zebrafish embryos to polystyrene nanoplastics at environmentally relevant concentrations and used single-cell RNA sequencing to identify hair cell-specific transcriptional changes in the inner ear, finding molecular-level effects without overt developmental phenotypes.
Effects of Microplastic (MP) Exposure at Environmentally Relevant Doses on the Structure, Function, and Transcriptome of the Kidney in Mice
Researchers exposed mice to polystyrene microplastics at doses matching levels found in the environment and examined the effects on kidney structure and function. While the microplastics did not cause obvious physical damage to the kidneys, they altered blood markers of kidney function and changed gene expression patterns related to immune response and metabolism. The study suggests that even low-level microplastic exposure may subtly affect kidney biology at the molecular level.
Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet-Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis.
A long-term mouse study examined how chronic exposure to polystyrene microspheres interacts with a high-fat diet to affect obesity-related outcomes, finding that microplastics worsened metabolic disruption and fat accumulation compared to diet alone. The results raise concern that microplastic exposure may be an environmental factor contributing to the global obesity epidemic.