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Original research — experimental, observational, or case-control study. Direct primary evidence.
Human Health Effects
Nanoplastics
Remediation
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The effect of polystyrene nanoplastics on arsenic-induced apoptosis in HepG2 cells
Ecotoxicology and Environmental Safety2023
9 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 50
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Chengyong Li
Zhenqing Dai,
Lei He,
Lei He,
Lei He,
Lei He,
Lei He,
Lei He,
Baoyi Tan,
Lihua Ma,
Chengyong Li
Lihua Ma,
Zifan Lu,
Linhong Yan,
Linhong Yan,
Baoyi Tan,
Lihua Ma,
Linhong Yan,
Linhong Yan,
Ruikun Sun,
Zhenqing Dai,
Lei He,
Lei He,
Ruikun Sun,
Chengyong Li
Zijie Wu,
Zijie Wu,
Zhenqing Dai,
Zifan Lu,
Zifan Lu,
Zifan Lu,
Zijie Wu,
Zijie Wu,
Lei He,
Lei He,
Lei He,
Lei He,
Lei He,
Lei He,
Lei He,
Zifan Lu,
Zifan Lu,
Lei He,
Yubin Zhang,
Zifan Lu,
Chengyong Li
Lei He,
Lei He,
Baoyi Tan,
Lihua Ma,
Lei He,
Zhenqing Dai,
Zhenqing Dai,
Lei He,
Baoyi Tan,
Zhenqing Dai,
Lei He,
Ruikun Sun,
Linhong Yan,
Lei He,
Zhenqing Dai,
Zhenqing Dai,
Linhong Yan,
Linhong Yan,
Ruikun Sun,
Zhenqing Dai,
Lei He,
Lei He,
Zhenqing Dai,
Ruikun Sun,
Ruikun Sun,
Ruikun Sun,
Lei He,
Lei He,
Lei He,
Lei He,
Lei He,
Linhong Yan,
Linhong Yan,
Linhong Yan,
Lei He,
Lihua Ma,
Xiaoling Dong,
Lei He,
Ruikun Sun,
Zhenqing Dai,
Lei He,
Xiaoling Dong,
Zhenqing Dai,
Zhenqing Dai,
Zhenqing Dai,
Xiaoling Dong,
Zhenqing Dai,
Zijie Wu,
Zhenqing Dai,
Shengli Sun,
Zhenqing Dai,
Chengyong Li
Zijie Wu,
Shengli Sun,
Lihua Ma,
Zhenqing Dai,
Zifan Lu,
Xiaoling Dong,
Zhenqing Dai,
Ruikun Sun,
Zhenqing Dai,
Zhenqing Dai,
Zhenqing Dai,
Chengyong Li
Ruikun Sun,
Lei He,
Lei He,
Zijie Wu,
Zifan Lu,
Xiaoling Dong,
Xiaoling Dong,
Zhenqing Dai,
Zhenqing Dai,
Zhenqing Dai,
Zhenqing Dai,
Zijie Wu,
Ruikun Sun,
Zhenqing Dai,
Chengyong Li
Zijie Wu,
Lihua Ma,
Lihua Ma,
Shengli Sun,
Shengli Sun,
Zijie Wu,
Zifan Lu,
Ruikun Sun,
Chengyong Li
Zhenqing Dai,
Ruikun Sun,
Shengli Sun,
Zhenqing Dai,
Zhenqing Dai,
Shengli Sun,
Shengli Sun,
Zhenqing Dai,
Zhenqing Dai,
Ruikun Sun,
Zhenqing Dai,
Shengli Sun,
Shengli Sun,
Chengyong Li
Zhenqing Dai,
Ruikun Sun,
Shengli Sun,
Shengli Sun,
Shengli Sun,
Ruikun Sun,
Zhenqing Dai,
Chengyong Li
Chengyong Li
Chengyong Li
Lei He,
Chengyong Li
Chengyong Li
Chengyong Li
Zhenqing Dai,
Chengyong Li
Zhenqing Dai,
Zhenqing Dai,
Chengyong Li
Shengli Sun,
Shengli Sun,
Shengli Sun,
Chengyong Li
Chengyong Li
Chengyong Li
Chengyong Li
Chengyong Li
Chengyong Li
Baoyi Tan,
Ruikun Sun,
Chengyong Li
Chengyong Li
Zhenqing Dai,
Baoyi Tan,
Lei He,
Zhenqing Dai,
Chengyong Li
Ruikun Sun,
Chengyong Li
Shengli Sun,
Lei He,
Zhenqing Dai,
Chengyong Li
Chengyong Li
Chengyong Li
Chengyong Li
Shengli Sun,
Chengyong Li
Chengyong Li
Chengyong Li
Chengyong Li
Shengli Sun,
Shengli Sun,
Chengyong Li
Chengyong Li
Chengyong Li
Chengyong Li
Shengli Sun,
Chengyong Li
Chengyong Li
Chengyong Li
Chengyong Li
Summary
Researchers studied the combined effects of polystyrene nanoplastics and arsenic on human liver cells in the laboratory. They found that nanoplastics, particularly those around 50 nanometers in size, significantly enhanced arsenic-induced cell death by disrupting mitochondrial function. The study identifies key genes involved in this interaction, suggesting that microplastic exposure may worsen the toxic effects of heavy metals on liver cells.
Microplastics are detrimental to the environment. However, the combined effects of microplastics and arsenic (As) remain unclear. In this study, we investigated the combined effects of polystyrene (PS) microplastics and As on HepG2 cells. The results showed that PS microplastics 20, 50, 200, and 500 nm in size were taken up by HepG2 cells, causing a decrease in cellular mitochondrial membrane potential. The results of lactate dehydrogenase release and flow cytometry showed that PS microplastics, especially those of 50 nm, enhanced As-induced apoptosis. In addition, transcriptome analysis revealed that TP53, AKT1, CASP3, ACTB, BCL2L1, CASP8, XIAP, MCL1, NFKBIA, and CASP7 were the top 10 hub genes for PS that enhanced the role of As in HepG2 cell apoptosis. Our results suggest that nano-PS enhances As-induced apoptosis. Furthermore, this study is important for a better understanding of the role of microplastics in As-induced hepatotoxicity.