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Polystyrene Microplastics Exacerbate Candida albicans Infection Ability In Vitro and In Vivo
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Researchers found that polystyrene microplastics can worsen Candida albicans fungal infections in both cell culture and animal models. In lab tests with human intestinal cells and in wax moth larvae, the presence of microplastics promoted more severe infection outcomes. The study provides new experimental evidence that microplastic exposure may increase vulnerability to opportunistic fungal infections.
Plastic pollution is an important environmental problem, and microplastics have been shown to have harmful effects on human and animal health, affecting immune and metabolic physiological functions. Further, microplastics can interfere with commensal microorganisms and exert deleterious effects on exposure to pathogens. Here, we compared the effects of 1 µm diameter polystyrene microplastic (PSMPs) on Candida albicans infection in both in vitro and in vivo models by using HT29 cells and Galleria mellonella larvae, respectively. The results demonstrated that PSMPs could promote Candida infection in HT29 cells and larvae of G. mellonella, which show immune responses similar to vertebrates. In this study, we provide new experimental evidence for the risk to human health posed by PSMPs in conjunction with Candida infections.
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Researchers found that exposure to polystyrene nanoparticles at low, environmentally realistic concentrations made a bacterial infection significantly more harmful to the roundworm C. elegans. The nanoparticles increased bacterial accumulation in the worms' bodies and weakened their innate immune responses. The study suggests that nanoplastic pollution in the environment could amplify the toxicity of common microbial pathogens.
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Researchers exposed the water flea Daphnia magna to two different parasites in the presence of polystyrene nanoplastics. The study found that nanoplastic exposure dramatically increased infection rates by a fungal parasite while having no significant effect on a gut microsporidium, suggesting that nanoplastics can differentially affect host-parasite relationships and potentially favor parasite coexistence in aquatic environments.
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