We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Polystyrene nanoplastics exposure causes inflammation and death of esophageal cell
Summary
Researchers exposed human esophageal cells to polystyrene nanoplastics and found that the particles triggered significant inflammation and cell death. The nanoplastics activated inflammatory signaling pathways and caused oxidative damage to the cells at concentrations relevant to human dietary exposure. The findings raise concerns about the potential effects of nanoplastic contamination in food and drinking water on the upper digestive tract.
Nanoplastics (NPs) are widely detected in food and drinking water, and human exposure to NPs is ubiquitous. The digestive tract is the main route of exposure to NPs in humans, and the esophagus is one of the main target organs for NPs exposure. However, the toxicological effects of polystyrene nanoplastics (PS-NPs) on the esophagus are not fully understood. Here, we used two esophageal cell lines as models to explore the effects of NPs exposure on esophageal cells and the underlying molecular mechanisms. Western blot analysis, indirect immunofluorescence assay, and enzyme-linked immunosorbent assay revealed that NPs exposure caused inflammatory responses and cell death. Mechanistic investigations showed that PS-NPs exposure induced iron overload in esophageal cells, leading to the accumulation of mitochondrial reactive oxygen species and promoting inflammatory responses and cell death. Additionally, PS-NPs treatment suppressed mitochondrial autophagy, which exacerbated NP-induced cell inflammation and death. Collectively, our experimental findings provide new evidence for the toxicological effects of PS-NPs and offer new insights and avenues for future research.
Sign in to start a discussion.
More Papers Like This
Nano-plastics and gastric health: Decoding the cytotoxic mechanisms of polystyrene nano-plastics size
Researchers examined how different sizes of polystyrene nanoplastics affect human stomach cells in the laboratory. They found that smaller nanoplastics were more readily taken up by the cells and caused greater damage, including increased oxidative stress and reduced cell survival. The study suggests that nanoplastic particle size plays a critical role in determining their potential impact on gastrointestinal health.
Pro-Inflammatory and Cytotoxic Effects of Polystyrene Microplastics on Human and Murine Intestinal Cell Lines
Researchers tested the effects of polystyrene microplastics on human and mouse intestinal cell lines. They found that microplastic exposure increased cell death and triggered inflammatory responses, including the release of inflammatory signaling molecules. The study suggests that microplastics may promote inflammation in the gut lining, which could have implications for digestive health.
Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity
Researchers found that polystyrene microplastics accumulate mainly in stomach tissue, where smaller nanoscale particles cause more severe damage than larger ones. The nanoplastics reduced antioxidant enzyme activity, increased DNA damage markers, and activated signaling pathways associated with cancer development. These size-dependent effects on the gastrointestinal tract suggest that the smallest plastic particles may pose the greatest risk to digestive health.
Polystyrene nanoparticles induce DNA damage and apoptosis in HeLa cells
Researchers exposed human HeLa cells to polystyrene nanoplastics — particles smaller than 100 nm — and found that even short exposures at low concentrations caused DNA damage, abnormal cell division, and signs of cell death including apoptosis and necrosis. The results suggest nanoplastics can directly damage human cell DNA, raising concerns about the health implications of everyday nanoplastic exposure.
Molecular effects of polystyrene nanoplastics on human neural stem cells
Researchers exposed human brain stem cells to tiny polystyrene nanoplastics and found they caused oxidative stress, DNA damage, inflammation, and cell death. These findings suggest that nanoplastics could potentially harm brain development if they reach neural tissue, though more research is needed to understand real-world exposure levels.