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In This Issue on 07-October-2024
Summary
This journal issue summary highlights a study that exposed male mice to polystyrene microplastics through oral ingestion for 28 and 56 days. The researchers found significant decreases in sperm concentration, motility, and normal sperm proportion, along with increased inflammatory markers. When tested on cultured Sertoli cells (which support sperm development), the microplastics penetrated the cells and triggered inflammatory responses, providing evidence that microplastic ingestion can cause male reproductive dysfunction in mammals.
This study aimed to reveal sex differences in the prevalence and severity of chronic cough in South Korea, stratified by age and etiology.It included 625 adult patients from 19 respiratory centers.Results showed a female predominance (67%), with a male-to-female ratio of 1:2.03.Female patients were older and more likely to have asthma/cough variant asthma (CVA).There was no difference in cough duration or severity between sexes.The proportion of females with cough increased with age, particularly in the 50s, 60s, and 70-89 age groups.Understanding these differences could enhance cough-related pathophysiology and treatment strategies. Examining the Relationship Between PolystyreneMicroplastics and Male Fertility: Insights From an In Vivo Study and In Vitro Sertoli Cell Culture.Tae BS, et al.This study investigated the effects of polystyrene microplastics (PS-MPs) on the reproductive system of male mice.Thirty mice were divided into six groups and exposed to PS-MPs via oral gavage for 28 and 56 days.Sperm analysis and protein evaluations were conducted.Results showed significant differences in sperm concentration, motility, and normal sperm proportion between groups.Increased levels of TGF-, HIF2, and NOX-4 were observed.In vitro, PS-MPs penetrated Sertoli cells and increased inflammatory protein expressions.The study concluded that PS-MPs induce reproductive dysfunction in male mice, providing insights into PS-MPs-associated toxicity in mammals.