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In This Issue on 07-October-2024
Summary
This journal issue summary highlights a study that exposed male mice to polystyrene microplastics through oral ingestion for 28 and 56 days. The researchers found significant decreases in sperm concentration, motility, and normal sperm proportion, along with increased inflammatory markers. When tested on cultured Sertoli cells (which support sperm development), the microplastics penetrated the cells and triggered inflammatory responses, providing evidence that microplastic ingestion can cause male reproductive dysfunction in mammals.
This study aimed to reveal sex differences in the prevalence and severity of chronic cough in South Korea, stratified by age and etiology.It included 625 adult patients from 19 respiratory centers.Results showed a female predominance (67%), with a male-to-female ratio of 1:2.03.Female patients were older and more likely to have asthma/cough variant asthma (CVA).There was no difference in cough duration or severity between sexes.The proportion of females with cough increased with age, particularly in the 50s, 60s, and 70-89 age groups.Understanding these differences could enhance cough-related pathophysiology and treatment strategies. Examining the Relationship Between PolystyreneMicroplastics and Male Fertility: Insights From an In Vivo Study and In Vitro Sertoli Cell Culture.Tae BS, et al.This study investigated the effects of polystyrene microplastics (PS-MPs) on the reproductive system of male mice.Thirty mice were divided into six groups and exposed to PS-MPs via oral gavage for 28 and 56 days.Sperm analysis and protein evaluations were conducted.Results showed significant differences in sperm concentration, motility, and normal sperm proportion between groups.Increased levels of TGF-, HIF2, and NOX-4 were observed.In vitro, PS-MPs penetrated Sertoli cells and increased inflammatory protein expressions.The study concluded that PS-MPs induce reproductive dysfunction in male mice, providing insights into PS-MPs-associated toxicity in mammals.
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More Papers Like This
Examining the Relationship Between Polystyrene Microplastics and Male Fertility: Insights From an In Vivo Study and In Vitro Sertoli Cell Culture
This study found that polystyrene microplastics caused reproductive damage in male mice, disrupting the cells that support sperm development (Sertoli cells). The microplastics interfered with normal reproductive function in both live mice and cell cultures. These findings add to growing evidence that microplastic exposure could contribute to declining male fertility, a trend already observed in humans worldwide.
Polystyrene microplastics induced male reproductive toxicity in mice
Researchers exposed male mice to polystyrene microplastics of different sizes and found that the particles accumulated in testicular tissue and entered reproductive cells. After 28 days of exposure, sperm quality and testosterone levels declined, and tissue examination revealed disorganized sperm-producing cells and inflammation. The study suggests that microplastic exposure may pose risks to male reproductive health in mammals.
Effects of polystyrene microparticles exposures on spermatogenic cell differentiation and reproductive endpoints in male mice
Researchers found that very small polystyrene microplastics (0.1 micrometers) accumulated in mouse testicular tissue and sperm-producing cells, leading to reduced sperm quality and impaired reproductive function. The particles triggered oxidative stress and disrupted the normal process of sperm cell development. This study adds to growing evidence that microplastic exposure could contribute to male fertility problems in humans, particularly from the smallest particles that can penetrate reproductive tissues.
Polystyrene microplastics cause reproductive toxicity in male mice
Male mice exposed to polystyrene microplastics for six weeks showed significant reproductive damage, including reduced sperm count and motility, lower testosterone levels, and visible tissue damage in the testes. The microplastics caused oxidative stress and triggered cell death pathways in the reproductive tissue. These findings add to growing evidence that microplastic exposure could contribute to declining male fertility.
Impact of polystyrene microplastic exposure at low doses on male fertility: an experimental study in rats
Researchers exposed adult male rats to varying doses of polystyrene microplastics and found dose-dependent declines in semen quality along with disrupted reproductive hormone levels. Higher doses caused increased oxidative stress, mitochondrial damage, and inflammatory responses in testicular tissue. The study suggests that even relatively low doses of microplastic exposure may have adverse effects on male reproductive health in animal models.