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Microplastics Antagonize the Therapeutic Effect of Curcumin on Nasopharyngeal Carcinoma Through Inhibiting the Apoptosis Pathway
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Higher number of microplastics in tumoral colon tissues from patients with colorectal adenocarcinoma
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Researchers found higher concentrations of microplastics in cancerous colon tissue compared to healthy tissue from the same patients, suggesting a possible link between microplastic accumulation and colorectal cancer, though this study cannot yet establish whether microplastics cause the disease.
Microplastic Accumulation in the Human Lung: Distinct Signatures in Lung Cancer vs Normal Tissue
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Scientists found tiny plastic particles (from things like packaging and bottles) in all the lung tissue samples they studied, both cancerous and healthy. Cancer samples tended to have more plastic bits, especially smaller fiber-shaped pieces made of common plastics like polypropylene and PET, but this was a small study, so it can't yet prove plastics cause cancer, just that they're worth investigating further. Bottom line: this adds to growing evidence that microplastics are showing up in our bodies, and researchers want to know if they're contributing to lung disease.
Micro-nano Plastics: Development of Carcinogenicity
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Researchers reviewed how micro- and nanoplastics may contribute to cancer development, examining the biological pathways by which these particles — now found throughout the human body — could trigger cell damage, inflammation, and potentially carcinogenic processes.
Micro(Nano)Plastics and the Risk of Cancer Development: Calling for Attention to a Macro Issue
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Researchers examined the potential role of micro- and nanoplastics in cancer development, reviewing mechanistic evidence for how these ubiquitous particles may disrupt cellular processes and promote tumor-associated pathways. The paper calls for greater scientific and regulatory attention to the oncological risks of chronic low-level plastic particle exposure.
Polystyrene Microplastics Disrupt Anticancer Proteins: An In Silico and In Vitro Study
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Molecular docking and cell culture experiments showed that polystyrene microplastics act as competitive inhibitors of melatonin receptors MT1 and MT2 — proteins central to anticancer signaling — and bind strongly to complement immune regulators Factor H and Factor I, while also inducing cytotoxicity and apoptosis in colon and breast cancer cell lines. These findings suggest microplastic exposure may interfere with the body's own cancer-suppression and immune regulatory mechanisms at the molecular level.
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