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Article
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AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button.
Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Nanoplastics
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Biobased, biodegradable but not bio-neutral: about the effects of polylactic acid nanoparticles on macrophages
Environmental Science Nano
2024
2 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Véronique Collin‐Faure,
Marianne Vitipon,
Marianne Vitipon,
Hélène Diemer,
Sarah Cianférani,
Élisabeth Darrouzet,
Thierry Rabilloud
Summary
When immune cells called macrophages encounter polylactic acid (PLA) nanoparticles — a supposedly biobased and biodegradable plastic — they can degrade the particles but trigger a range of cellular stress responses in the process. This challenges the idea that bioplastics are biologically inert, suggesting that 'biodegradable' does not mean 'harmless' once particles enter the body.
Macrophages treated with polylactide beads degrade them but show various responses in the meantime.