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Developmental Toxicity of PEDOT:PSS in Zebrafish: Effects on Morphology, Cardiac Function, and Intestinal Health

Toxics 2024 10 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Guan Yang, De‐Sheng Pei Marriya Sultan, Guan Yang, De‐Sheng Pei Marriya Sultan, De‐Sheng Pei De‐Sheng Pei Marriya Sultan, Marriya Sultan, De‐Sheng Pei Dongzhi Gou, Dongzhi Gou, De‐Sheng Pei Marriya Sultan, Xingyi Wei, Marriya Sultan, De‐Sheng Pei De‐Sheng Pei Dongzhi Gou, De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei Marriya Sultan, De‐Sheng Pei De‐Sheng Pei Ling-Kang Bu, Ling-Kang Bu, De‐Sheng Pei Xingyi Wei, De‐Sheng Pei Marriya Sultan, De‐Sheng Pei Huan Hu, Marriya Sultan, De‐Sheng Pei Guan Yang, De‐Sheng Pei De‐Sheng Pei Guan Yang, De‐Sheng Pei Xingyi Wei, Wenbo Huo, De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei Marriya Sultan, De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei De‐Sheng Pei

Summary

Researchers found that PEDOT:PSS, a conductive polymer used in electronics and biomedical devices, was toxic to developing zebrafish, causing oxidative stress, reduced activity, heart development problems, and intestinal cell damage. This is important because as conductive polymers become more common in wearable technology and medical implants, their breakdown into micro- and nano-sized particles could pose health risks. The study highlights the need to evaluate the safety of new synthetic materials before widespread use.

Body Systems

Cardiovascular

Models

Zebrafish

Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a conductive polymer commonly used in various technological applications. However, its impact on aquatic ecosystems remains largely unexplored. In this study, we investigated the toxicity effects of PEDOT:PSS on zebrafish. We first determined the lethal concentration (LC<sub>50</sub>) of PEDOT:PSS in zebrafish and then exposed AB-type zebrafish embryos to different concentrations of PEDOT:PSS for 120 h. Our investigation elucidated the toxicity effects of zebrafish development, including morphological assessments, heart rate measurements, behavioral analysis, transcriptome profiling, and histopathological analysis. We discovered that PEDOT:PSS exhibited detrimental effects on the early developmental stages of zebrafish, exacerbating the oxidative stress level, suppressing zebrafish activity, impairing cardiac development, and causing intestinal cell damage. This study adds a new dimension to the developmental toxicity of PEDOT:PSS in zebrafish. Our findings contribute to our understanding of the ecological repercussions of PEDOT:PSS and highlight the importance of responsible development and application of novel materials in our rapidly evolving technological landscape.

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