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Human Health Effects
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Polystyrene microplastic‐induced endoplasmic reticulum stress contributes to growth plate endochondral ossification disorder in young rat
Environmental Toxicology2024
17 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 60
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Yang Liu,
Qingqing Zhang,
Yuanyuan Lang,
Yuanyuan Lang,
Hengyi Xu,
Yanling Liu,
Yang Liu,
Xiaomin Tang,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Yang Liu,
Yang Liu,
Yang Liu,
Yang Liu,
Yang Liu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Wenshu Cheng,
Yang Liu
Wenshu Cheng,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Zugen Cheng,
Yang Liu,
Zugen Cheng,
Yang Liu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Mohammad Rizwan,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Mohammad Rizwan,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Hengyi Xu,
Lixin Xie,
Hengyi Xu,
Yang Liu,
Yanling Liu,
Yang Liu,
Hengyi Xu,
Yang Liu,
Yang Liu
Summary
Researchers found that polystyrene microplastics caused growth problems and bone damage in young rats by triggering stress in a part of the cell called the endoplasmic reticulum. This stress disrupted the normal process by which cartilage turns into bone in growing animals. The findings raise concerns that microplastic exposure during early development could interfere with normal bone growth in children.
These results indicated that MPs could induce growth retardation and longitudinal bone damage in early development. The toxicity of MPs may attribute to induced ER stress and impaired essential processes of the endochondral ossification after MPs exposure.