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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Sign in to save

Polystyrene microplastic‐induced endoplasmic reticulum stress contributes to growth plate endochondral ossification disorder in young rat

Environmental Toxicology 2024 17 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Qingqing Zhang, Yuanyuan Lang, Xiaomin Tang, Wenshu Cheng, Zugen Cheng, Mohammad Rizwan, Lixin Xie, Yanling Liu, Yang Liu, Hengyi Xu, Yang Liu

Summary

Researchers found that polystyrene microplastics caused growth problems and bone damage in young rats by triggering stress in a part of the cell called the endoplasmic reticulum. This stress disrupted the normal process by which cartilage turns into bone in growing animals. The findings raise concerns that microplastic exposure during early development could interfere with normal bone growth in children.

Polymers
PS
Models
Rat

These results indicated that MPs could induce growth retardation and longitudinal bone damage in early development. The toxicity of MPs may attribute to induced ER stress and impaired essential processes of the endochondral ossification after MPs exposure.

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