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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Nanoplastics Sign in to save

Polystyrene Nanoplastics Induce Pyroptosis in HepG2 Cells via the YAP1-cGAS-STING Signaling Axis.

PubMed 2026
Yi Yang, Zuodong Liu, Mao Cao, Jiazi Ma, Mengjie Cheng, Lei Meng, Lei Meng, Guanqun Cui, Zhaoxia Du

Summary

Scientists found that tiny plastic particles from polystyrene (commonly used in disposable cups and food containers) can trigger a harmful type of cell death in liver cells. When these microscopic plastic pieces enter liver cells, they activate a specific pathway that causes the cells to essentially self-destruct, which could potentially damage the liver over time. This research helps explain how the plastic pollution we're exposed to daily might be harming our bodies, particularly our liver health.

Polymers
PS
Body Systems
Hepatic

These findings indicate that PS-NPs promote hepatocyte pyroptosis through the YAP1-cGAS-STING pathway, with YAP1 serving as a central regulator, providing mechanistic insight into PS-NPs-induced liver toxicity and identifying YAP1 as a potential therapeutic target.

Read via DOI PubMed

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