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Formulation and evaluation of hydrocortisone micro beads
Summary
Researchers formulated and evaluated hydrocortisone micro-beads for controlled drug delivery, testing bead formation methods, drug encapsulation efficiency, and release kinetics. The optimized formulation showed sustained hydrocortisone release over several hours and maintained drug stability, supporting its development as a controlled-release platform for anti-inflammatory therapy.
The current study aimed to develop hydrocortisone mucoadhesive microbeads to prolong the drug's action in the gastrointestinal system, targeting Crohn's disease treatment. Hydrocortisone, known for its anti - inflammatory and anti - rheumatic effects, was util ized in bead form to enhance therapeutic efficacy, extend residence time, and reduce dosage frequency. Using sodium alginate, HPMC, and Eudragit L - 100 as adhesive polymers, and calcium chloride and aluminium chloride as cross - linking agents, the study craf ted microbeads with an entrapment efficiency between 57.23% and 91.69%. Evaluations focused on in vitro drug release, particle size, surface characteristics, entrapment efficiency, and the role of cross - linking ions. Of the formulations, HCS - 8 (with sodium alginate and Eudragit L - 100 using aluminium chloride as the gelling solution) and HCS - 2 showed optimal drug release profiles. Notably, HCS - 8 achieved a 12 - hour drug release delay, attributed to aluminium chloride's cross - linking action. Drug release kinet ics revealed a zero - order linearity (R2=0.99), suggesting super case 2 transport as the primary release mechanism.