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Polymer-Specific Quantification of Circulating Microplastics in Healthy and Immunocompromised Individuals
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Scientists found tiny plastic particles in the blood of all people they tested, but people with weakened immune systems had slightly higher levels than healthy people. The plastic pieces likely come from everyday items and medical equipment, and people with compromised immune systems may have trouble clearing them from their bodies. This research shows that microplastics are now circulating in human blood, though we still don't know what health effects this might have.
Abstract Background Microplastics (MPs) are emerging contaminants of global concern that have recently been identified in the human blood. However, their presence in immunocompromised people is still not much identified. This research offers the comparative evaluation of MP load in normal and immunocompromised patients. Methods Blood samples were collected from healthy individuals (n = 15) and immunocompromised patients (n = 20) by using non-plastic equipments. Samples were subjected to acid (1M HCl, 1M HNO3) and alkaline (1M NaOH, 1.8M KOH) digestion. Polymer identification was performed on 14 representative samples using ATR-FTIR spectroscopy. An updated quantifying technique that minus both blank and biological control residues enhanced a more precise way of quantification. Results All analyzed blood samples contained microplastics (MPs). The refined digestion method yielded MP between 0.2 and 7.0 gL-1 with a mean ±SD of 2.86 ±1.80 g L-1. The findings showed that MP load in the immunocompromised was higher (3.57±1.55 g L-1) compared to healthy controls (1.90 ±1.93 g L-1) but the difference was not statistically significant (unpaired t = 1.99, p = 0.073). Environmental and medical sources were represented by such dominant polymers as polyacrylamide (PAM 25%), polyaramid (PA 20%), and polybutylene terephthalate (PBT 14%). The maximum recovery and polymer integrity was obtained with HCl digestion. Conclusion This study found microplastics in both normal and immunocompromised blood samples but load was higher in immunocompromised patients probably due to clinical exposure to polymer and its minimal clearance. These findings highlight the need for standardized analytical protocols and further investigation into the biological implications of circulating microplastics.
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