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Plastiome: Plastisphere-enriched mobile resistome in aquatic environments

Journal of Hazardous Materials 2024 20 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 65 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Amila Abeynayaka Amila Abeynayaka Keerthi S. Guruge, Keerthi S. Guruge, Prasun Goswami, Prasun Goswami, Prasun Goswami, Prasun Goswami, Prasun Goswami, Prasun Goswami, Prasun Goswami, Kazuki Kanda, Prasun Goswami, Prasun Goswami, Amila Abeynayaka Prasun Goswami, Kazuki Kanda, Yukino Tamamura-Andoh, Kazuki Kanda, Amila Abeynayaka Amila Abeynayaka Mafumi Watanabe, Mafumi Watanabe, Amila Abeynayaka Amila Abeynayaka Masahiko Kumagai, Masahiko Kumagai, Keerthi S. Guruge, Mafumi Watanabe, Mafumi Watanabe, Mafumi Watanabe, Mafumi Watanabe, Yukino Tamamura-Andoh, Amila Abeynayaka Yukino Tamamura-Andoh, Mafumi Watanabe, Amila Abeynayaka Amila Abeynayaka Amila Abeynayaka

Summary

Researchers studying two Japanese rivers near Tokyo found that microplastics floating in the water carry communities of bacteria harboring antibiotic resistance genes that can be transferred between organisms. This collection of mobile resistance genes on plastics, which they call the "plastiome," could help spread antibiotic resistance through waterways, posing an indirect but significant threat to human health.

Polymers

PE PP

Study Type Environmental

Aquatic microplastics (MPs) act as reservoirs for microbial communities, fostering the formation of a mobile resistome encompassing diverse antibiotic (ARGs) and biocide/metal resistance genes (BMRGs), and mobile genetic elements (MGEs). This collective genetic repertoire, referred to as the "plastiome," can potentially perpetuate environmental antimicrobial resistance (AMR). Our study examining two Japanese rivers near Tokyo revealed that waterborne MPs are primarily composed of polyethylene and polypropylene fibers and sheets of diverse origin. Clinically important genera like Exiguobacterium and Eubacterium were notably enriched on MPs. Metagenomic analysis uncovered a 3.46-fold higher enrichment of ARGs on MPs than those in water, with multidrug resistance genes (MDRGs) and BMRGs prevailing, particularly within MPs. Specific ARG and BMRG subtypes linked to resistance to vancomycin, beta-lactams, biocides, arsenic, and mercury showed selective enrichment on MPs. Network analysis revealed intense associations between host genera with ARGs, BMRGs, and MGEs on MPs, emphasizing their role in coselection. In contrast, river water exhibited weaker associations. This study underscores the complex interactions shaping the mobile plastiome in aquatic environments and emphasizes the global imperative for research to comprehend and effectively control AMR within the One Health framework.

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