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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Environmental Sources Human Health Effects Nanoplastics Sign in to save

Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes

Particle and Fibre Toxicology 2024 27 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Yunyi Wang, Ke Xu, Ke Xu, Xiao Gao, Zhaolan Wei, Qi Han, Shuxin Wang, Wanting Du, Mingqing Chen

Summary

A study found that polystyrene nanoplastics can induce symptoms similar to type 2 diabetes, and the severity depends on the surface charge of the particles. Positively charged (amino-modified) nanoplastics caused the most serious blood sugar regulation problems by interfering with insulin signaling, suggesting that as plastics age and their surface chemistry changes, their health risks may increase.

Polymers
PS

Exposure to PS-NPs with different functional groups (charges) induced T2DM-like lesions. Amino-modified PS-NPs cause more serious T2DM-like lesions than pristine PS-NPs or carboxyl functionalized PS-NPs. The underlying mechanisms involved the inhibition of P-AKT/P-FoxO1. This study highlights the potential risk of NPs pollution on T2DM, and provides a new perspective for evaluating the impact of plastics aging.

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