The biodistribution of polystyrene nanoparticles administered intravenously in the chicken embryo
Environment International2024
11 citations
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Score: 50
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Martina G. Vijver,
Meiru Wang,
Meiru Wang,
Michael K. Richardson
Meiru Wang,
Meiru Wang,
Martina G. Vijver,
Shuhao Chen,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Tom A.P. Nederstigt,
Tom A.P. Nederstigt,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Tom A.P. Nederstigt,
Meiru Wang,
Meiru Wang,
Shuhao Chen,
Robert E. Poelmann,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Robert E. Poelmann,
Shixiong Cheng,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Tom A.P. Nederstigt,
Martina G. Vijver,
Robert E. Poelmann,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Marco C. DeRuiter,
Gerda E. M. Lamers,
Gerda E. M. Lamers,
Gerda E. M. Lamers,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Joost Willemse,
Martina G. Vijver,
Martina G. Vijver,
Gerda E. M. Lamers,
Chiara Mascitelli,
Chiara Mascitelli,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Martina G. Vijver,
Michael K. Richardson
Martina G. Vijver,
Martina G. Vijver,
Shixiong Cheng,
Shixiong Cheng,
Martina G. Vijver,
Martina G. Vijver,
Michael K. Richardson
Michael K. Richardson
Summary
Researchers injected polystyrene nanoplastics into chicken embryos and tracked where the particles traveled, finding high accumulations in the heart, liver, and kidneys, with particles crossing critical tissue barriers. This is an important advance in understanding how nanoplastics distribute throughout a developing organism, with potential implications for fetal health.
Nanoplastics can cause severe malformations in chicken embryos. To improve our understanding of the toxicity of nanoplastics to embryos, we have studied their biodistribution in living chicken embryos. We injected the embryos in the vitelline vein at stages 18-19. We injected polystyrene nanoparticles (PS-NPs) tagged with europium- or fluorescence. Their biodistribution was tracked using inductively-coupled plasma mass spectrometry on tissue lysates, paraffin histology, and vibratome sections analysed by machine learning algorithms. PS-NPs were found at high levels in the heart, liver and kidneys. Furthermore, PS-NPs crossed the endocardium of the heart at sites of epithelial-mesenchymal transformation; they also crossed the liver endothelium. Finally, we detected PS-NPs in the allantoic fluid, consistent with their being excreted by the kidneys. Our study shows the power of the chicken embryo model for analysing the biodistribution of nanoplastics in embryos. Such experiments are difficult or impossible in mammalian embryos. These findings are a major advance in our understanding of the biodistribution and tissue-specific accumulation of PS-NPs in developing animals.