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The damaging effects of polyethylene microplastics exposure on juvenile carp and the ameliorative role of Opuntia Milpa alta extract
Summary
Researchers exposed juvenile carp to polyethylene microplastics for 45 days, documenting liver damage, inflammation, and gut microbiota disruption, then found that Opuntia cactus extract significantly reduced liver enzyme markers and restored microbial diversity, suggesting natural plant extracts may help counteract microplastic toxicity.
In recent years, the pollution of microplastics (MPs) in water ecosystems has gained much attention. Polyethylene microplastics (PE-MPs) are stable and can accumulate in organisms, causing harm to fish and other aquatic life. This study used juvenile carp to examine the toxic effects of PE-MPs and the potential benefits of Opuntia Milpa alta extract. We optimized fluorescence labeling to prepare 30 µm PE-MPs and analyzed their distribution in juvenile carp. The results showed that they mainly accumulate in the liver and intestines, with some in the kidneys and gills. A 45-d exposure study revealed that PE-MPs caused liver cell damage, inflammation, and increased liver function biomarkers (AST, ALT, ALP) (P < 0.05). There was also a decrease in gut microbiota diversity and an increase in harmful bacteria like Desulfovibrionaceae. The intervention with Opuntia Milpa alta extract (0.50%, 1.00%, 2.00% in feed) significantly reduced AST and ALT levels (P < 0.05), improved liver health, and restored gut microbiota diversity. Analysis of the extract showed it contains bioactive substances like polysaccharides (23.15%) and alkaloids (55.96%). These components likely enhance liver function and balance gut health by modulating the gut-liver connection. This study offers new insights into ecotoxicological measures for microplastic pollution and suggests that natural plant extracts can help protect environmental health.