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Human Health Effects
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Coexposure to microplastic and Bisphenol A exhacerbates damage to human kidney proximal tubular cells
Heliyon2024
12 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 60
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Sebastiano La Maestra,
Daniela Verzola,
Edoardo La Porta,
Sebastiano La Maestra,
Edoardo La Porta,
Sebastiano La Maestra,
Sebastiano La Maestra,
Edoardo La Porta,
Noemi Rumeo,
Noemi Rumeo,
Daniela Verzola,
Edoardo La Porta,
Daniela Verzola,
Daniela Verzola,
Noemi Rumeo,
Noemi Rumeo,
Cristina Artini
Andrea Angeletti,
Stefano Alberti,
Stefano Alberti,
Stefano Alberti,
Edoardo La Porta,
Enrico Verrina,
Pasquale Esposito,
Pasquale Esposito,
Stefano Alberti,
Stefano Alberti,
Cristina Artini
Fabrizio Loiacono,
Francesca Viazzi,
Francesca Viazzi,
Daniela Verzola,
Andrea Angeletti,
Stefano Alberti,
Stefano Alberti,
Stefano Alberti,
Paolo Cravedi,
Sebastiano La Maestra,
Daniela Verzola,
Andrea Angeletti,
Mario Passalacqua,
Sebastiano La Maestra,
Andrea Angeletti,
Stefano Alberti,
Mario Passalacqua,
Noemi Rumeo,
Enrico Verrina,
Enrico Verrina,
Paolo Cravedi,
Cristina Artini
Micaela Gentile,
Paolo Cravedi,
Micaela Gentile,
Andrea Angeletti,
Paolo Cravedi,
Daniela Verzola,
Edoardo La Porta,
Elisa Russo,
Pasquale Esposito,
Paolo Cravedi,
Andrea Angeletti,
Pasquale Esposito,
Micaela Gentile,
Cristina Artini
Micaela Gentile,
Enrico Verrina,
Stefano Alberti,
Andrea Angeletti,
Andrea Angeletti,
Andrea Angeletti,
Cristina Artini
Simona Matarese,
Simona Matarese,
Noemi Rumeo,
Noemi Rumeo,
Enrico Verrina,
Enrico Verrina,
Nicoletta Mancianti,
Micaela Gentile,
Enrico Verrina,
Paolo Cravedi,
Edoardo La Porta,
Nicoletta Mancianti,
Micaela Gentile,
Pasquale Esposito,
Micaela Gentile,
Micaela Gentile,
Paolo Cravedi,
Stefano Alberti,
Enrico Verrina,
Francesca Viazzi,
Francesca Viazzi,
Sebastiano La Maestra,
Micaela Gentile,
Micaela Gentile,
Daniela Verzola,
Pasquale Esposito,
Daniela Verzola,
Pasquale Esposito,
Pasquale Esposito,
Pasquale Esposito,
Francesca Viazzi,
Francesca Viazzi,
Edoardo La Porta,
Francesca Viazzi,
Stefano Alberti,
Daniela Verzola,
Pasquale Esposito,
Enrico Verrina,
Edoardo La Porta,
Francesca Viazzi,
Nicoletta Mancianti,
Edoardo La Porta,
Cristina Artini
Summary
This study exposed human kidney cells to polyethylene microplastics and bisphenol A (BPA, a common plastic chemical) together and found the combination was significantly more damaging than either substance alone. The co-exposure reduced cell survival and increased both oxidative stress and inflammation in the kidney cells. Since both microplastics and BPA are commonly found in the human body, their combined effect on kidney health is a real concern.
Microplastics (MPs) accumulate in tissues, including kidney tissue, while Bisphenol A (BPA) is a plasticizer of particular concern. At present, the combined effects of MPs and BPA are unexplored in human renal cells. Therefore, we exposed a proximal tubular cell line (PTECs) to polyethylene (PE)-MPs and BPA, both separately and in combination. When co-exposed, cells showed a significantly reduced cell viability (MTT test) and a pronounced pro-oxidant (MDA levels, NRF2 and NOX4 expression by Western blot) and pro-inflammatory response (IL1β, CCL/CCR2 and CCL/CCR5 mRNAs by RT-PCR), compared to those treated with a single compound. In addition, heat shock protein (HSP90), a chaperone involved in multiple cellular functions, was reduced (by Western Blot and immunocytochemistry), while aryl hydrocarbon receptor (AHR) expression, a transcription factor which binds environmental ligands, was increased (RT-PCR and immunofluorescence). Our research can contribute to the study of the nephrotoxic effects of pollutants and MPs and shed new light on the combined effects of BPA and PE-MPs.