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Investigating the impact of nanoplastics in altering the efficacy of clarithromycin antibiotics through In vitro studies
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Researchers investigated how polystyrene nanoplastics interact with the antibiotic clarithromycin and affect both insulin structure and bacterial resistance. They found that nanoplastics can adsorb the antibiotic, leading to structural changes in insulin that could potentially contribute to insulin resistance, while also reducing the antibiotic's ability to inhibit pathogenic bacteria. The findings highlight the complex ways nanoplastics may interfere with pharmaceutical efficacy.
Plastics have significant global implications due to their environmental contamination from extensive use and improper disposal. Among plastic particles, nanoplastics (<1 μm) pose notable risks to organisms and ecosystems due to their high surface area, reactivity, and potential to carry environmental pollutants. This study explores the interaction between polystyrene nanoplastics (PSNPs) and clarithromycin (CLA), a broad-spectrum antibiotic, focusing on their combined impact on insulin (INS) and antibiotic-resistant (AMR) bacteria. PSNPs can adsorb CLA, leading to structural changes in insulin and affecting its physiological functions, potentially causing insulin resistance. Additionally, PSNPs reduce CLA's inhibitory effects on pathogenic bacteria, facilitating antibiotic resistance. Our research utilized UV-Vis Spectroscopy, FTIR, Fluorescence spectroscopy, and Circular dichroism (CD) spectroscopy to assess INS structural changes, alongside the Kirby-Bauer disk diffusion method for microbiological examination. The findings highlight the synergistic and antagonistic effects of PSNPs and CLA, underscoring the enhanced toxicity of CLA when adsorbed onto PSNPs and the complex interactions affecting both human health and bacterial resistance. Further studies are essential to fully understand these mechanisms and their broader implications.
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Adsorption of clarithromycin on polystyrene nanoplastics surface and its combined adverse effect on serum albumin
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Researchers examined how the antibiotic clarithromycin binds to the surface of polystyrene nanoplastics and how this combination interacts with blood proteins. They found that the drug readily adsorbed onto the nanoplastic surface and that the drug-nanoplastic complex altered the structure and function of serum albumin more than either substance alone. The findings suggest that nanoplastics could amplify the biological effects of pharmaceutical pollutants by acting as carriers in the body.
Insights into the interaction mechanism of ofloxacin and functionalized nano-polystyrene.
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This study investigated how the antibiotic ofloxacin interacts with functionalized polystyrene nanoplastics, finding that surface charge and functional groups on the nanoplastics strongly influenced binding strength and mechanisms. The results improve understanding of how nanoplastics can act as carriers for antibiotics in the environment, potentially altering their fate and biological effects.
Interactionsbetween Nanoplastics and Antibiotics:Implications for Nanoplastics Aggregation in Aquatic Environments
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Researchers studied how the antibiotics ciprofloxacin and tetracycline interact with polystyrene nanoplastics in aquatic environments, finding that these drugs alter nanoplastic surface properties and aggregation behavior under environmentally relevant conditions.
Surface interaction of vancomycin with polystyrene microplastics and its effect on human serum albumin
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Researchers studied how the antibiotic vancomycin interacts with polystyrene microplastics and what happens when that combination encounters human blood proteins. They found that vancomycin readily adsorbs onto microplastic surfaces, and that the resulting particle-drug complex can alter how the antibiotic binds to serum albumin in the blood. The study suggests that microplastics in the body could interfere with how medications are transported and function in the bloodstream.
Adsorption behavior and quantum chemical analysis of surface functionalized polystyrene nano-plastics on gatifloxacin.
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Researchers studied how three types of polystyrene nanoplastics — unmodified, amino-modified, and carboxyl-modified — adsorb the antibiotic gatifloxacin, finding that surface chemistry strongly influences uptake. This matters because nanoplastics that absorb antibiotics could serve as vectors carrying these pharmaceuticals into aquatic ecosystems and the organisms that live there.
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