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WITHDRAWN: Cytotoxic effects of polystyrene nanoplastics in different functional sizes on MDA-MB-231 breast cancer cells and HFF-2 cells
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This preprint has been withdrawn by the authors due to internal disagreement about its posting and should not be cited.
Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
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WITHDRAWN: Cytotoxic effects of polystyrene nanoplastics in different functional sizes on MDA-MB-231 breast cancer cells and HFF-2 cells
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This withdrawn study investigated the cytotoxic effects of polystyrene nanoplastics of different sizes on breast cancer cells and normal human fibroblasts, examining oxidative stress responses, cell cycle arrest, and apoptosis induction, though the paper was subsequently retracted from publication.
Toxic effects of polystyrene nanoplastics on MDA-MB-231 breast cancer and HFF-2 normal fibroblast cells: viability, cell death, cell cycle and antioxidant enzyme activity
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Researchers exposed human breast cancer cells and normal skin cells to polystyrene nanoplastics and found that smaller particles at higher concentrations caused significant cell death through apoptosis (programmed cell death) and reduced the cells' ability to defend against oxidative damage. The dose- and size-dependent toxicity suggests that nanoplastics small enough to enter cells are more biologically harmful than larger particles.
Cytotoxicity and pro-inflammatory effect of polystyrene nano-plastic and micro-plastic on RAW264.7 cells.
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Researchers found that polystyrene nano-plastics (80 nm) induced apoptosis and pro-inflammatory cytokine release in mouse macrophage RAW264.7 cells at lower concentrations than micro-plastics (3 μm), with nano-plastics also enhancing phagocytic activity and activating NF-kB signaling pathways more potently than their larger counterparts.
Cellular Uptake and Nuclear Accumulation of Polystyrene Nanoplastics in 3T3 Fibroblasts and Hepatocytes of Rattus norvegicus
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Scientists found that tiny plastic particles called nanoplastics can get inside liver and connective tissue cells from rats, and even sneak into the cell's nucleus, where DNA is stored. Cells exposed to these plastics showed signs of stress and damage, including swelling and higher rates of cell death, suggesting these ultra-small plastic particles may be more harmful than previously thought. While this study used animal cells rather than human cells, it raises important questions about what everyday exposure to nanoplastics (found in food packaging, water, and other sources) might mean for our own cellular health.
Correction: Correlation between cellular uptake and cytotoxicity of polystyrene micro/nanoplastics in HeLa cells: A size-dependent matter
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This is a correction notice for a previously published study on the correlation between cellular uptake and cytotoxicity of polystyrene micro- and nanoplastics.
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