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Article ? AI-assigned paper type based on the abstract. Classification may not be perfect — flag errors using the feedback button. Tier 2 ? Original research — experimental, observational, or case-control study. Direct primary evidence. Human Health Effects Reproductive & Development Sign in to save

Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations

Frontiers in Endocrinology 2024 19 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Ashelley Sousa, Keyla Silva Nobre Pires, Isadora Hart Cavalcante, Iasmin Cristina Lira Cavalcante, Julia Domingues Santos, Maiara Ingrid Cavalcante Queiroz, Ana Catarina Rezende Leite, Alessandre Carmo Crispim, Edmilson Rodrigues da Rocha, Thiago Mendonça de Aquino, Rodrigo Barbano Weingrill, Johann Urschitz, Stephanie Ospina‐Prieto, Alexandre Urban Borbely

Summary

Researchers exposed human placental tissue to polystyrene microplastics in the lab and found that the particles caused increasing cell damage over time, along with oxidative stress and disruptions to key metabolic processes including energy production and folate metabolism. Folate is critical for fetal development, so interference with its metabolism is particularly concerning. This study adds to growing evidence that microplastic contamination could affect pregnancy outcomes and fetal health.

Polymers
PS
Body Systems
Reproductive

This study demonstrates that high concentrations of PS-MPs induce time-dependent cytotoxicity, oxidative stress, and alterations in the TCA cycle, as well as in folate, amino acid, and energy metabolism. These findings highlight the need for further research to clarify the full impact of MP contamination on pregnancy and its implications for future generations.

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