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Polystyrene microplastics exacerbate acetochlor-induced reproductive toxicity and transgenerational effects in zebrafish

Aquatic Toxicology 2024 14 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 60 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Yangyang Wang, Yangyang Wang, Yangyang Wang, Yangyang Wang, Chaofan Ma, Chaofan Ma, Chaofan Ma, Chaofan Ma, Chaofan Ma, Chaofan Ma, Chaofan Ma, Chaofan Ma, Hongwu Liang Chaofan Ma, Chaofan Ma, Chaofan Ma, Chaofan Ma, Zenglong Chen, Yangyang Wang, Hongwu Liang Hongwu Liang Yangyang Wang, Zenglong Chen, Yinping Guo, Chaofan Ma, Yinping Guo, Yinping Guo, Yinping Guo, Yinping Guo, Chaofan Ma, Yangyang Wang, Hongwu Liang Chaofan Ma, Chaofan Ma, Yinping Guo, Yinping Guo, Yinping Guo, Yinping Guo, Yinping Guo, Xiaolei Chen, Xiaolei Chen, Jing Yuan, Jing Yuan, Xiaolei Chen, Xiaolei Chen, Jing Yuan, Jing Yuan, Hongwu Liang Hongwu Liang Hongwu Liang Hongwu Liang Hongwu Liang

Summary

This zebrafish study found that polystyrene microplastics made the herbicide acetochlor significantly more toxic to the reproductive system, and the damage was passed down to the next generation. The microplastics acted as carriers for the pesticide, increasing its absorption and worsening hormone disruption and fertility problems. This is concerning because both microplastics and agricultural chemicals are commonly found together in waterways, where their combined effects may be greater than previously understood.

Polymers

Body Systems

Endocrine Hepatic Musculoskeletal Nervous Reproductive

Models

Zebrafish

Microplastic (MPs) can adsorb co-existing pollutants, and alter their behavior and toxicity. Meanwhile, amide herbicides like acetochlor (ACT) are widely used in agriculture, with potential endocrine-disrupting effects that raise ecological concerns. The aim of this research was to examine the effects of MPs on the reproductive endocrine disruption caused by ACT and the effects of maternal transmission. Zebrafish were employed in this study to assess the reproductive toxicity of ACT alone and in combination with polystyrene microplastics (PS-MPs) of different sizes (200 nm and 2 μm) and concentrations (0.1 and 1 mg/L) over a 63-day exposure experiment. The results indicated that ACT was concentrated in zebrafish tissues in the order: intestine > liver > gill > brain > gonad > muscle. PS-MPs increased ACT bioaccumulation, worsened gonadal damage, led to abnormalities in hormone levels, and caused disruptions in HPG axis gene expression, further exacerbating the reproductive toxicity. Maternal transfer of ACT affected offspring growth, thyroid function, and HPT axis gene expression, with nanoplastics (NPS) amplifying these adverse effects. This study offers crucial insights into the ecological hazards posed by ACT and PS-MPs, emphasizing the increased toxicity due to PS-MPs.

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