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In vivo hepatic effects and post-exposure recovery following polyethylene terephthalate microplastic ingestion in Swiss Albino mice (Mus musculus)
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Researchers exposed Swiss Albino mice to two concentrations of PET microplastics for 14 days via drinking water, finding significant liver enzyme disruption and oxidative stress markers, followed by a 7-day depuration period that showed partial recovery of some but not all biomarkers.
The study focuses on the in vivo toxicity of two concentrations of Polyethylene Terephthalate (PET) microplastics (MPs) (average size 30.22 ± 10.21 µm; 1 mg/mL and 2 mg/mL in distilled water) in Swiss Albino mice after 14 days of exposure via their feeding bottles, followed by a depuration period of 7 days. After 14 days of exposure, PET-MPs induced significant effects on the activities of Alanine Aminotransferase (ALT), Catalase (CAT) and Superoxide Dismutase (SOD) in the liver (p < 0.001). Additionally, the levels of total carbohydrates, total proteins, Reduced Glutathione (GSH) and Thiobarbituric acid reactive substances (TBARS) were also significantly altered (p < 0.001; p < 0.01 for proteins). Upon completion of the depuration phase, parameters largely reverted to baseline although several remained statistically distinct from the control values, except for GSH and TBARS. Genotoxicity assessed by the comet assay was not observed with the concentrations used in the study.
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In vivo hepatic effects and post-exposure recovery following polyethylene terephthalate microplastic ingestion in Swiss Albino mice ( Mus musculus )
AI summary Read the abstract
Swiss albino mice ingested two concentrations of polyethylene terephthalate (PET) microplastics for 14 days, followed by a 7-day recovery period, and researchers assessed liver enzyme activity and tissue damage. PET-MPs caused significant hepatotoxicity at both concentrations, with partial—but incomplete—recovery of liver function after the exposure period ended.
In vivo hepatic effects and post-exposure recovery following polyethylene terephthalate microplastic ingestion in Swiss Albino mice (Mus musculus)
AI summary Read the abstract
This in vivo study found that ingesting PET microplastics at 1 and 2 mg/mL for 14 days caused significant liver toxicity in mice—including disrupted ALT, catalase, and SOD enzyme activity—with partial but incomplete recovery after a 7-day depuration period.
Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis
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Researchers exposed mice to PET microplastics ground from plastic bottles over 29 weeks and found that the particles caused obesity, liver enlargement, fatty liver disease, and early-stage scarring of liver tissue. The microplastics also disrupted gut bacteria and bile acid metabolism, pointing to damage along the gut-liver connection. The findings raise concerns about the long-term health effects of chronic exposure to the type of microplastics commonly found in food and beverages.
Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice
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Researchers found that mice exposed to PET microplastics (the type commonly found in plastic bottles) over 17 weeks developed liver damage, including fat buildup, oxidative stress, and cell death. The study revealed that the damage was driven by changes in gut bacteria that altered lipid metabolism, and when researchers depleted the gut bacteria, the liver damage was reduced. This suggests the gut microbiome plays a key role in how microplastics cause harm to internal organs.
Renal and Hepatotoxic Effects of Polyethylene Terephthalate Microplastics in Chronically Exposed Albino Rats
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Researchers exposed albino rats to different doses of PET microplastics for 90 days and measured kidney and liver function markers. They found that chronic exposure led to significant changes in serum urea, creatinine, and liver enzymes, suggesting potential kidney and liver damage at higher doses. The study also found that water stored in PET containers exposed to sunlight showed similar toxic effects, raising concerns about everyday plastic container use.
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