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Oxidative damage and intestinal microbial imbalance induced by polystyrene microplastics and cadmium in zebrafish (Danio rerio)
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“Biochemical impacts of polyethylene terephthalate microplastics and cadmium on Danio rerio under environmental conditions”
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Twenty-one-day exposures of zebrafish to PET microplastics—alone and combined with the heavy metal cadmium—caused oxidative protein damage and disrupted energy metabolism, with the mixture producing worse effects than either pollutant alone. This synergistic toxicity is significant because fish in real-world waterways encounter microplastics and heavy metals together, making combined-exposure studies critical for assessing actual ecological and food-safety risks.
Feeding, excretion, survival, and histological alterations in zebrafish Danio rerio from single and combined exposure to microplastics and copper
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Researchers exposed zebrafish to microplastics and copper individually and in combination over 14 days, finding that combined exposure caused the most severe histological damage across multiple organ systems including skin, gills, intestine, liver, and kidneys, while microplastic excretion rates declined over time and copper tissue levels were unaffected by co-exposure.
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