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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Human Health Effects
Nanoplastics
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Synergistic neurotoxicity of polystyrene nanoplastics and cadmium co-exposure: oxidative stress, mitochondrial dysfunction, and ATF5-mediated mitochondrial unfolded protein response in C. elegans and PC12 cells
Environmental Science Nano
2025
Shuyan Niu,
Yu Ma,
Menghao Guo,
Haitao Yang,
Liqing Wu,
Chenyu Liu,
Mengjing Cui,
Tianshu Wu,
Yuying Xue
Summary
This study found that co-exposure to polystyrene nanoplastics and cadmium produced synergistic neurotoxicity in C. elegans and PC12 cells, mediated through oxidative stress, mitochondrial dysfunction, and activation of the ATF5-dependent mitochondrial unfolded protein response pathway.
Synergistic neurotoxicity of PS-NPs and Cd co-exposure: oxidative stress, mitochondrial dysfunction, and ATF5-mediated UPR mt in C. elegans and PC12 cells.