Molecular mechanism underlying the modulated toxicity of differently charged and sized nanoplastics by bovine serum albumin

Molecular mechanism underlying the modulated toxicity of differently charged and sized nanoplastics by bovine serum albumin

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This study examined how bovine serum albumin modulates the toxicity of polystyrene nanoplastics with different charges and sizes in biological systems. Serum albumin formed a protein corona that reduced the toxicity of negatively charged nanoplastics but had less protective effect against positively charged particles.

The effects of nanoplastics on toxicity of metals and metal nanoparticles: molecular mechanisms and health effects

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Researchers reviewed how co-exposure to nanoplastics and heavy metals produces synergistic toxicity across multiple species and cell models, finding that nanoplastics enhance metal bioavailability and amplify oxidative stress, mitochondrial dysfunction, apoptosis, and gut dysbiosis more severely than equivalent microplastic co-exposures.

Polystyrene nanoplastics amplify arsenite-induced toxicity to human serum albumin: Potentiated inhibition via complexation

Nanoplastic-Induced Biological Effects In Vivo and In Vitro: An Overview

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Researchers reviewed how nanoplastics accumulate in and harm living organisms, finding that particle size, surface charge, exposure dose, and duration all influence toxicity — with smaller, charged particles penetrating cells more readily and chemical additives amplifying harm beyond the plastics themselves.

Abstract 1036 A Biochemical Investigation on the Structural Integrity of Bovine Serum Albumin During Exposure to Plastic Particles

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This biochemical study investigated how microplastics and nanoplastics at varying concentrations affect the structural integrity of bovine serum albumin, finding that plastic particles induce conformational changes in the protein that may indicate broader impacts on biological macromolecules.