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The Combined Exposure to Polystyrene Nanoplastics and Bisphenol a Results in Mitochondrial Damage and Ferroptosis Via the Pi3k-Akt Signaling Pathway in the Kidneys of Mice
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Combined exposure to polystyrene nanoplastics and bisphenol A results in mitochondrial damage and ferroptosis via the PI3K-AKT signaling pathway in mice kidneys
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Researchers exposed mice to polystyrene nanoplastics combined with bisphenol A for six weeks and found that co-exposure caused significant kidney damage through mitochondrial dysfunction and a form of cell death called ferroptosis. The combined exposure was more harmful than either contaminant alone, operating through the PI3K-AKT signaling pathway. The findings suggest that nanoplastics acting as carriers for co-pollutants like BPA may amplify toxic effects on kidney tissue.
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Researchers exposed mice to cadmium and polystyrene nanoplastics individually and together, finding that co-exposure synergistically worsened kidney damage by activating PANoptosis — a coordinated cell death cascade integrating pyroptosis, apoptosis, and necroptosis — with the scaffold protein ASC markedly upregulated as a central driver.
Co-exposure of arsenic and polystyrene-nanoplastics induced kidney injury by disrupting mitochondrial homeostasis and mtROS-mediated ferritinophagy and ferroptosis
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Researchers found that arsenic and polystyrene nanoplastics together — but not separately — cause kidney fibrosis in mice by disrupting mitochondrial function and triggering a form of iron-dependent cell death called ferroptosis, with mitochondria-targeted antioxidants significantly reducing the combined damage.
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Cytotoxicity of Polystyrene Nanoplastics Involves Mitochondrial Dysfunction and DNA Damage in Hemocytes of the Pacific Oyster
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Scientists found that tiny plastic particles (nanoplastics) can damage the immune cells of oysters by harming their mitochondria, the "batteries" that power cells, leading to DNA damage even at low exposure levels. While this study was done in oysters, not humans, it adds to growing evidence that nanoplastics can disrupt basic cell functions, raising questions about what similar exposure might mean for human health given how widespread plastic pollution has become in our food and water.
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