0
Article Tier 2 Human Health Effects Sign in to save

Polystyrene Microplastics Exposure Disrupts Blood-Testis Barrier Via Oma1-Dependent Cleavage of Dele1 and Protective Effect of N-Acetylcysteine in Mice

No summary available — this paper's abstract is not included in the open metadata provided by the publisher. Learn why →

Polymers
Models

More Papers Like This

Article Tier 2

Occurrence, toxicity and removal of polystyrene microplastics and nanoplastics in human sperm

AI summary Read the abstract

Researchers detected polystyrene microplastics in human semen and showed they reduce sperm function, then demonstrated that magnetic iron oxide nanoparticles can remove nanoplastics from semen samples — offering an early glimpse into both the reproductive health threat posed by microplastics and potential mitigation strategies.

Article Tier 2

Biochemical, Histological and Molecular Docking into the Impact of Polystyrene Nanoplastics on Antioxidant Enzymes and Testicular Health in Rats

AI summary Read the abstract

Tiny plastic particles called nanoplastics, found widely in our environment, may harm male fertility, according to a new rat study. Rats exposed to higher doses of these plastics showed weakened antioxidant defenses and physical damage to testicular tissue, including fewer developing sperm cells. While this research was done in rats, not humans, it adds to growing concerns that the microplastics and nanoplastics we're routinely exposed to through food, water, and air could pose risks to reproductive health.

Article Tier 2

Prenatal exposure to polystyrene nanoplastics caused testicular development toxicities and relative mechanisms in male offspring mice from embryo to adulthood

AI summary Read the abstract

Scientists exposed pregnant mice to nanoplastics (tiny plastic particles found in our environment, blood, and even placentas) and found their male offspring had slowed growth before birth, hit puberty earlier, and had reduced fertility as adults. The nanoplastics appeared to disrupt key genes and cells needed for normal testicle development and hormone production. While this is animal research, it adds to growing evidence that plastic exposure during pregnancy could affect a baby's reproductive development later in life.

Article Tier 2

Polystyrene Microplastics Disrupt Anticancer Proteins: An In Silico and In Vitro Study

AI summary Read the abstract

Molecular docking and cell culture experiments showed that polystyrene microplastics act as competitive inhibitors of melatonin receptors MT1 and MT2 — proteins central to anticancer signaling — and bind strongly to complement immune regulators Factor H and Factor I, while also inducing cytotoxicity and apoptosis in colon and breast cancer cell lines. These findings suggest microplastic exposure may interfere with the body's own cancer-suppression and immune regulatory mechanisms at the molecular level.

Article Tier 2

Unraveling the endocrine disruption potential of microplastics in testosterone regulation

AI summary Read the abstract

Researchers reviewed in vivo evidence that microplastics impair testosterone synthesis through multiple converging mechanisms — oxidative damage to Leydig cells, disruption of the LH/cAMP/StAR steroidogenesis cascade, NF-κB inflammation, and endoplasmic reticulum stress — while flagging a critical gap in human data and the largely unexplored role of physicochemical diversity among plastic types.

Research digests by email

When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.

Email me about

Share this paper